Loading…
Sortilin Expression Levels and Peripheral Immunity: A Potential Biomarker for Segregation between Parkinson's Disease Patients and Healthy Controls
Parkinson's disease (PD) is characterized by substantial phenotypic heterogeneity that limits the disease prognosis and patient's counseling, and complicates the design of further clinical trials. There is an unmet need for the development and validation of biomarkers for the prediction of...
Saved in:
Published in: | International journal of molecular sciences 2024-02, Vol.25 (3), p.1791 |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | |
---|---|
cites | cdi_FETCH-LOGICAL-c447t-212ae5d411314196a0c17c178c8dc64a54a245f96094c954551ab0c5a7231b603 |
container_end_page | |
container_issue | 3 |
container_start_page | 1791 |
container_title | International journal of molecular sciences |
container_volume | 25 |
creator | Georgoula, Maria Ntavaroukas, Panagiotis Androutsopoulou, Anastasia Xiromerisiou, Georgia Kalala, Fani Speletas, Matthaios Asprodini, Eftihia Vasilaki, Anna Papoutsopoulou, Stamatia |
description | Parkinson's disease (PD) is characterized by substantial phenotypic heterogeneity that limits the disease prognosis and patient's counseling, and complicates the design of further clinical trials. There is an unmet need for the development and validation of biomarkers for the prediction of the disease course. In this study, we utilized flow cytometry and in vitro approaches on peripheral blood cells and isolated peripheral blood mononuclear cell (PBMC)-derived macrophages to characterize specific innate immune populations in PD patients versus healthy donors. We found a significantly lower percentage of B lymphocytes and monocyte populations in PD patients. Monocytes in PD patients were characterized by a higher CD40 expression and on-surface expression of the type I membrane glycoprotein sortilin, which showed a trend of negative correlation with the age of the patients. These results were further investigated in vitro on PBMC-derived macrophages, which, in PD patients, showed higher sortilin expression levels compared to cells from healthy donors. The treatment of PD-derived macrophages with oxLDL led to higher foam cell formation compared to healthy donors. In conclusion, our results support the hypothesis that surface sortilin expression levels on human peripheral monocytes may potentially be utilized as a marker of Parkinson's disease and may segregate the sporadic versus the genetically induced forms of the disease. |
doi_str_mv | 10.3390/ijms25031791 |
format | article |
fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_556ca9d8f57e4c47ab1531c8bda77398</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A782090958</galeid><doaj_id>oai_doaj_org_article_556ca9d8f57e4c47ab1531c8bda77398</doaj_id><sourcerecordid>A782090958</sourcerecordid><originalsourceid>FETCH-LOGICAL-c447t-212ae5d411314196a0c17c178c8dc64a54a245f96094c954551ab0c5a7231b603</originalsourceid><addsrcrecordid>eNptkk1v1DAQhiMEoqVw44wscYADW_yZxNyWpdCVKrFS4RxNnMnWS2JvbS-wv4M_jMOWUhCyJVuvn3nHY09RPGX0VAhNX9vNGLmiglWa3SuOmeR8RmlZ3b-zPyoexbihlAuu9MPiSNRTaKmPix-XPiQ7WEfOvm8Dxmi9Ixf4FYdIwHVkhcFurzDAQJbjuHM27d-QOVn5hC7ZrL61foTwBQPpfSCXuA64hjS5tJi-ITqyysfWRe9eRPLORoSIWUs2GxxynCMM6WpPFt6l4If4uHjQwxDxyc16Unx-f_ZpcT67-PhhuZhfzIyUVZpxxgFVJxkTTDJdAjWsyrM2dWdKCUoCl6rXJdXSaCWVYtBSo6DigrUlFSfF8uDbedg022BzIfvGg21-CT6sG8iPYwZslCoN6K7uVYXSyApapgQzddtBVQldZ6-XB69t8Nc7jKkZbTQ4DODQ72LDdf4jSmvBM_r8H3Tjd8HlSidK6IqXjP6h1pDzW9f7FMBMps28qjnVVKsp7el_qDw6HK3xDnub9b8CXh0CTPAxBuxv62a0mZqiudtPGX92c9ddO2J3C_9uIPETsiTEog</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2923972610</pqid></control><display><type>article</type><title>Sortilin Expression Levels and Peripheral Immunity: A Potential Biomarker for Segregation between Parkinson's Disease Patients and Healthy Controls</title><source>Open Access: PubMed Central</source><source>Publicly Available Content (ProQuest)</source><creator>Georgoula, Maria ; Ntavaroukas, Panagiotis ; Androutsopoulou, Anastasia ; Xiromerisiou, Georgia ; Kalala, Fani ; Speletas, Matthaios ; Asprodini, Eftihia ; Vasilaki, Anna ; Papoutsopoulou, Stamatia</creator><creatorcontrib>Georgoula, Maria ; Ntavaroukas, Panagiotis ; Androutsopoulou, Anastasia ; Xiromerisiou, Georgia ; Kalala, Fani ; Speletas, Matthaios ; Asprodini, Eftihia ; Vasilaki, Anna ; Papoutsopoulou, Stamatia</creatorcontrib><description>Parkinson's disease (PD) is characterized by substantial phenotypic heterogeneity that limits the disease prognosis and patient's counseling, and complicates the design of further clinical trials. There is an unmet need for the development and validation of biomarkers for the prediction of the disease course. In this study, we utilized flow cytometry and in vitro approaches on peripheral blood cells and isolated peripheral blood mononuclear cell (PBMC)-derived macrophages to characterize specific innate immune populations in PD patients versus healthy donors. We found a significantly lower percentage of B lymphocytes and monocyte populations in PD patients. Monocytes in PD patients were characterized by a higher CD40 expression and on-surface expression of the type I membrane glycoprotein sortilin, which showed a trend of negative correlation with the age of the patients. These results were further investigated in vitro on PBMC-derived macrophages, which, in PD patients, showed higher sortilin expression levels compared to cells from healthy donors. The treatment of PD-derived macrophages with oxLDL led to higher foam cell formation compared to healthy donors. In conclusion, our results support the hypothesis that surface sortilin expression levels on human peripheral monocytes may potentially be utilized as a marker of Parkinson's disease and may segregate the sporadic versus the genetically induced forms of the disease.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms25031791</identifier><identifier>PMID: 38339069</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adaptor Proteins, Vesicular Transport - genetics ; Adaptor Proteins, Vesicular Transport - metabolism ; B cells ; Biomarkers - metabolism ; Cells ; Cytokines ; Development and progression ; Disease ; Ethylenediaminetetraacetic acid ; Flow cytometry ; Humans ; Immune system ; Immunity (Disease) ; Kinases ; Leukocytes, Mononuclear - metabolism ; Lymphocytes ; Macrophages ; Medical research ; Medicine, Experimental ; monocytes ; Mutation ; Neurodegeneration ; Neurophysiology ; Older people ; Parkinson Disease ; Parkinson's disease ; Pathogenesis ; Patients ; peripheral immunity ; Proteins ; sortilin ; Tumor necrosis factor-TNF ; Type 2 diabetes</subject><ispartof>International journal of molecular sciences, 2024-02, Vol.25 (3), p.1791</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c447t-212ae5d411314196a0c17c178c8dc64a54a245f96094c954551ab0c5a7231b603</cites><orcidid>0000-0003-1287-7734 ; 0000-0001-6665-8508 ; 0000-0001-7162-3588 ; 0000-0002-0852-4883</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2923972610/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2923972610?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,37013,44590,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38339069$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Georgoula, Maria</creatorcontrib><creatorcontrib>Ntavaroukas, Panagiotis</creatorcontrib><creatorcontrib>Androutsopoulou, Anastasia</creatorcontrib><creatorcontrib>Xiromerisiou, Georgia</creatorcontrib><creatorcontrib>Kalala, Fani</creatorcontrib><creatorcontrib>Speletas, Matthaios</creatorcontrib><creatorcontrib>Asprodini, Eftihia</creatorcontrib><creatorcontrib>Vasilaki, Anna</creatorcontrib><creatorcontrib>Papoutsopoulou, Stamatia</creatorcontrib><title>Sortilin Expression Levels and Peripheral Immunity: A Potential Biomarker for Segregation between Parkinson's Disease Patients and Healthy Controls</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Parkinson's disease (PD) is characterized by substantial phenotypic heterogeneity that limits the disease prognosis and patient's counseling, and complicates the design of further clinical trials. There is an unmet need for the development and validation of biomarkers for the prediction of the disease course. In this study, we utilized flow cytometry and in vitro approaches on peripheral blood cells and isolated peripheral blood mononuclear cell (PBMC)-derived macrophages to characterize specific innate immune populations in PD patients versus healthy donors. We found a significantly lower percentage of B lymphocytes and monocyte populations in PD patients. Monocytes in PD patients were characterized by a higher CD40 expression and on-surface expression of the type I membrane glycoprotein sortilin, which showed a trend of negative correlation with the age of the patients. These results were further investigated in vitro on PBMC-derived macrophages, which, in PD patients, showed higher sortilin expression levels compared to cells from healthy donors. The treatment of PD-derived macrophages with oxLDL led to higher foam cell formation compared to healthy donors. In conclusion, our results support the hypothesis that surface sortilin expression levels on human peripheral monocytes may potentially be utilized as a marker of Parkinson's disease and may segregate the sporadic versus the genetically induced forms of the disease.</description><subject>Adaptor Proteins, Vesicular Transport - genetics</subject><subject>Adaptor Proteins, Vesicular Transport - metabolism</subject><subject>B cells</subject><subject>Biomarkers - metabolism</subject><subject>Cells</subject><subject>Cytokines</subject><subject>Development and progression</subject><subject>Disease</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Flow cytometry</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunity (Disease)</subject><subject>Kinases</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Lymphocytes</subject><subject>Macrophages</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>monocytes</subject><subject>Mutation</subject><subject>Neurodegeneration</subject><subject>Neurophysiology</subject><subject>Older people</subject><subject>Parkinson Disease</subject><subject>Parkinson's disease</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>peripheral immunity</subject><subject>Proteins</subject><subject>sortilin</subject><subject>Tumor necrosis factor-TNF</subject><subject>Type 2 diabetes</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkk1v1DAQhiMEoqVw44wscYADW_yZxNyWpdCVKrFS4RxNnMnWS2JvbS-wv4M_jMOWUhCyJVuvn3nHY09RPGX0VAhNX9vNGLmiglWa3SuOmeR8RmlZ3b-zPyoexbihlAuu9MPiSNRTaKmPix-XPiQ7WEfOvm8Dxmi9Ixf4FYdIwHVkhcFurzDAQJbjuHM27d-QOVn5hC7ZrL61foTwBQPpfSCXuA64hjS5tJi-ITqyysfWRe9eRPLORoSIWUs2GxxynCMM6WpPFt6l4If4uHjQwxDxyc16Unx-f_ZpcT67-PhhuZhfzIyUVZpxxgFVJxkTTDJdAjWsyrM2dWdKCUoCl6rXJdXSaCWVYtBSo6DigrUlFSfF8uDbedg022BzIfvGg21-CT6sG8iPYwZslCoN6K7uVYXSyApapgQzddtBVQldZ6-XB69t8Nc7jKkZbTQ4DODQ72LDdf4jSmvBM_r8H3Tjd8HlSidK6IqXjP6h1pDzW9f7FMBMps28qjnVVKsp7el_qDw6HK3xDnub9b8CXh0CTPAxBuxv62a0mZqiudtPGX92c9ddO2J3C_9uIPETsiTEog</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Georgoula, Maria</creator><creator>Ntavaroukas, Panagiotis</creator><creator>Androutsopoulou, Anastasia</creator><creator>Xiromerisiou, Georgia</creator><creator>Kalala, Fani</creator><creator>Speletas, Matthaios</creator><creator>Asprodini, Eftihia</creator><creator>Vasilaki, Anna</creator><creator>Papoutsopoulou, Stamatia</creator><general>MDPI AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-1287-7734</orcidid><orcidid>https://orcid.org/0000-0001-6665-8508</orcidid><orcidid>https://orcid.org/0000-0001-7162-3588</orcidid><orcidid>https://orcid.org/0000-0002-0852-4883</orcidid></search><sort><creationdate>20240201</creationdate><title>Sortilin Expression Levels and Peripheral Immunity: A Potential Biomarker for Segregation between Parkinson's Disease Patients and Healthy Controls</title><author>Georgoula, Maria ; Ntavaroukas, Panagiotis ; Androutsopoulou, Anastasia ; Xiromerisiou, Georgia ; Kalala, Fani ; Speletas, Matthaios ; Asprodini, Eftihia ; Vasilaki, Anna ; Papoutsopoulou, Stamatia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-212ae5d411314196a0c17c178c8dc64a54a245f96094c954551ab0c5a7231b603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adaptor Proteins, Vesicular Transport - genetics</topic><topic>Adaptor Proteins, Vesicular Transport - metabolism</topic><topic>B cells</topic><topic>Biomarkers - metabolism</topic><topic>Cells</topic><topic>Cytokines</topic><topic>Development and progression</topic><topic>Disease</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Flow cytometry</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunity (Disease)</topic><topic>Kinases</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Lymphocytes</topic><topic>Macrophages</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>monocytes</topic><topic>Mutation</topic><topic>Neurodegeneration</topic><topic>Neurophysiology</topic><topic>Older people</topic><topic>Parkinson Disease</topic><topic>Parkinson's disease</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>peripheral immunity</topic><topic>Proteins</topic><topic>sortilin</topic><topic>Tumor necrosis factor-TNF</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Georgoula, Maria</creatorcontrib><creatorcontrib>Ntavaroukas, Panagiotis</creatorcontrib><creatorcontrib>Androutsopoulou, Anastasia</creatorcontrib><creatorcontrib>Xiromerisiou, Georgia</creatorcontrib><creatorcontrib>Kalala, Fani</creatorcontrib><creatorcontrib>Speletas, Matthaios</creatorcontrib><creatorcontrib>Asprodini, Eftihia</creatorcontrib><creatorcontrib>Vasilaki, Anna</creatorcontrib><creatorcontrib>Papoutsopoulou, Stamatia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Directory of Open Access Journals</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Georgoula, Maria</au><au>Ntavaroukas, Panagiotis</au><au>Androutsopoulou, Anastasia</au><au>Xiromerisiou, Georgia</au><au>Kalala, Fani</au><au>Speletas, Matthaios</au><au>Asprodini, Eftihia</au><au>Vasilaki, Anna</au><au>Papoutsopoulou, Stamatia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sortilin Expression Levels and Peripheral Immunity: A Potential Biomarker for Segregation between Parkinson's Disease Patients and Healthy Controls</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>25</volume><issue>3</issue><spage>1791</spage><pages>1791-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Parkinson's disease (PD) is characterized by substantial phenotypic heterogeneity that limits the disease prognosis and patient's counseling, and complicates the design of further clinical trials. There is an unmet need for the development and validation of biomarkers for the prediction of the disease course. In this study, we utilized flow cytometry and in vitro approaches on peripheral blood cells and isolated peripheral blood mononuclear cell (PBMC)-derived macrophages to characterize specific innate immune populations in PD patients versus healthy donors. We found a significantly lower percentage of B lymphocytes and monocyte populations in PD patients. Monocytes in PD patients were characterized by a higher CD40 expression and on-surface expression of the type I membrane glycoprotein sortilin, which showed a trend of negative correlation with the age of the patients. These results were further investigated in vitro on PBMC-derived macrophages, which, in PD patients, showed higher sortilin expression levels compared to cells from healthy donors. The treatment of PD-derived macrophages with oxLDL led to higher foam cell formation compared to healthy donors. In conclusion, our results support the hypothesis that surface sortilin expression levels on human peripheral monocytes may potentially be utilized as a marker of Parkinson's disease and may segregate the sporadic versus the genetically induced forms of the disease.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38339069</pmid><doi>10.3390/ijms25031791</doi><orcidid>https://orcid.org/0000-0003-1287-7734</orcidid><orcidid>https://orcid.org/0000-0001-6665-8508</orcidid><orcidid>https://orcid.org/0000-0001-7162-3588</orcidid><orcidid>https://orcid.org/0000-0002-0852-4883</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1422-0067 |
ispartof | International journal of molecular sciences, 2024-02, Vol.25 (3), p.1791 |
issn | 1422-0067 1661-6596 1422-0067 |
language | eng |
recordid | cdi_doaj_primary_oai_doaj_org_article_556ca9d8f57e4c47ab1531c8bda77398 |
source | Open Access: PubMed Central; Publicly Available Content (ProQuest) |
subjects | Adaptor Proteins, Vesicular Transport - genetics Adaptor Proteins, Vesicular Transport - metabolism B cells Biomarkers - metabolism Cells Cytokines Development and progression Disease Ethylenediaminetetraacetic acid Flow cytometry Humans Immune system Immunity (Disease) Kinases Leukocytes, Mononuclear - metabolism Lymphocytes Macrophages Medical research Medicine, Experimental monocytes Mutation Neurodegeneration Neurophysiology Older people Parkinson Disease Parkinson's disease Pathogenesis Patients peripheral immunity Proteins sortilin Tumor necrosis factor-TNF Type 2 diabetes |
title | Sortilin Expression Levels and Peripheral Immunity: A Potential Biomarker for Segregation between Parkinson's Disease Patients and Healthy Controls |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T13%3A21%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sortilin%20Expression%20Levels%20and%20Peripheral%20Immunity:%20A%20Potential%20Biomarker%20for%20Segregation%20between%20Parkinson's%20Disease%20Patients%20and%20Healthy%20Controls&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Georgoula,%20Maria&rft.date=2024-02-01&rft.volume=25&rft.issue=3&rft.spage=1791&rft.pages=1791-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms25031791&rft_dat=%3Cgale_doaj_%3EA782090958%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c447t-212ae5d411314196a0c17c178c8dc64a54a245f96094c954551ab0c5a7231b603%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2923972610&rft_id=info:pmid/38339069&rft_galeid=A782090958&rfr_iscdi=true |