Vitamin D deficiency and lower urinary tract symptoms in males above 50 years of age

• Published in: Urology annals 2017-04, Vol.9 (2), p.170-173
• Main Authors: Elshazly, Mohamed Abdemonem, Sultan, Mohamed Farag, Aboutaleb, Hamdy Abdelmawla, Salem, Shady Mohamed, Aziz, Mohamed Sayedahmed, Abd Elbaky, Tarek Mohamed, Elsherif, Eid Abdelrasoul, Gawish, Maher Mohamed, Alajrawi, Feras Tarek, Elgadi, Fahd Abdulla Algady, Thaher, Awad Husein, Shebl, Mohamed Ahmed, Allam, Adel Mohamed, Kehinde, Elija
• Format: Article
• Language: English
• Subjects: Age; Benign prostatic hyperplasia; Bladder; lower urinary tract symptoms; Males; Older people; Original; Prostate cancer; Studies; Urogenital system; Vitamin D; Vitamin deficiency
• ISSN: 0974-7796; 0974-7834
• DOI: 10.4103/0974-7796.204192

Lower urinary tract symptoms (LUTSs) in elderly males are usually related to benign prostatic hyperplasia (BPH) in the majority of cases. It is estimated that BPH affects half of men above the age of 50 years. Recently, a relationship between Vitamin D deficiency and LUTS in elderly males has been reported. The aim of this study was to analyze Vitamin D levels in males aged above 50 years presenting with LUTS. This is a prospective case-control study. This was a case-control study in which males above 50 years of age who presented with LUTS (Group A) were compared with a control group (Group B) without LUTS. Both groups were investigated regarding Vitamin D level, prostate-specific antigen (PSA), International Prostatic Symptoms Score (IPSS), prostate size, flow rate, serum calcium levels, and abdominal ultrasonography. Statistical software package (SPSS Inc., Chicago, IL, USA) was used for the statistical analyses, performing -test for quantitative data to compare between the two groups. Pearson's correlation coefficient " " test was calculated between two quantitative, continuous variables in Group A. 0.05). The mean value of Vitamin D level was 40.82 ± 29.46 nmol/L in Group A and 70.25 ± 22.42 nmol/L in Group B ( < 0.001). The mean value of prostate size was 50.12 ± 23.24 g in Group A and 30.68 ± 4.90 g in Group B ( < 0.001). The mean serum calcium level was 2.4 ± 0.14 mmol/L and 2.50 ± 0.15 mmol/L in Groups A and B, respectively ( < 0.001). The mean value of PSA in Group A was 2.24 ± 1.95 ng/ml versus 2.11 ± 0.45 ng/ml in Group B ( < 0.001). The mean value of IPSS in Group A was 13.38 ± 5.32 ml/s versus 3.41 ± 2.42 ml/s in Group B. The mean value of Q max in uroflowmetry in Group A was 11.5 ± 2 ml/s versus 15.4 ± 1 ml/s in Group B. Men older than 50 years of age with LUTS have lower levels of Vitamin D compared to men without LUTS.