Ductal carcinoma in situ and sentinel lymph node metastasis in breast cancer

The impact of sentinel lymph node biopsy on breast cancer mimicking ductal carcinoma in situ (DCIS) is a matter of debate. We studied the rate of occurrence of sentinel lymph node metastasis in 255 breast cancer patients with pure DCIS showing no invasive components on routine pathological examinati...

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Bibliographic Details
Published in:World journal of surgical oncology 2010-01, Vol.8 (1), p.6-6, Article 6
Main Authors: Tada, Keiichiro, Ogiya, Akiko, Kimura, Kiyomi, Morizono, Hidetomo, Iijima, Kotaro, Miyagi, Yumi, Nishimura, Seiichiro, Makita, Masujiro, Horii, Rie, Akiyama, Futoshi, Iwase, Takuji
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biopsy
Breast cancer
Breast Neoplasms - pathology
Carcinoma, Ductal, Breast - secondary
Carcinoma, Intraductal, Noninfiltrating - secondary
Care and treatment
Development and progression
Diagnosis
Female
Humans
Incidence
Lymph nodes
Lymph Nodes - pathology
Lymphatic Metastasis
Middle Aged
Neoplasm Staging
Prognosis
Risk factors
Sentinel Lymph Node Biopsy
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Summary:The impact of sentinel lymph node biopsy on breast cancer mimicking ductal carcinoma in situ (DCIS) is a matter of debate. We studied the rate of occurrence of sentinel lymph node metastasis in 255 breast cancer patients with pure DCIS showing no invasive components on routine pathological examination. We compared this to the rate of occurrence in 177 patients with predominant intraductal-component (IDC) breast cancers containing invasive foci equal to or less than 0.5 cm in size. Most of the clinical and pathological baseline characteristics were the same between the two groups. However, peritumoral lymphatic permeation occurred less often in the pure DCIS group than in the IDC-predominant invasive-lesion group (1.2% vs. 6.8%, p = 0.002). One patient (0.39%) with pure DCIS had two sentinel lymph nodes positive for metastasis. This rate was significantly lower than that in patients with IDC-predominant invasive lesions (6.2%; p < 0.001). Because the rate of sentinel lymph node metastasis in pure DCIS is very low, sentinel lymph node biopsy can safely be omitted.
ISSN:1477-7819
1477-7819
DOI:10.1186/1477-7819-8-6