DNA damage in acute myeloid leukemia patients of Northern Mexico

The purpose of this study was to evaluate DNA damage in the whole genome of peripheral blood leukocytes from patients with acute myeloid leukemia (AML) compared with a control group using DNA breakage detection-fluorescent in situ hybridization (DBD-FISH). Our results suggest that the DNA damage det...

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Bibliographic Details
Published in:European journal of histochemistry 2017-12, Vol.61 (4), p.2851-2851
Main Authors: Dávila-Rodríguez, Martha I, Cortés-Gutiérrez, Elva I, Hernández-Valdés, Roberto, Guzmán-Cortés, Karla, De León-Cantú, Rosa E, Cerda-Flores, Ricardo M, Báez-De la Fuente, Enrique
Format: Article
Language:English
Subjects:
acute myeloid leukemia
Adult
Brief Report
DNA breakage detection-fluorescence in situ hybridization
DNA Damage
Humans
Leukemia, Myeloid, Acute - physiopathology
Mexico
Middle Aged
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Summary:The purpose of this study was to evaluate DNA damage in the whole genome of peripheral blood leukocytes from patients with acute myeloid leukemia (AML) compared with a control group using DNA breakage detection-fluorescent in situ hybridization (DBD-FISH). Our results suggest that the DNA damage detected in patients with newly diagnosed AML was similar to that observed for the controls; this might be explained by the stimulation of a repair pathway by the pathogenesis itself. These findings indicate that inhibiting the repair pathway could be proposed to enhance the efficacy of chemotherapy.
ISSN:1121-760X
2038-8306
DOI:10.4081/ejh.2017.2851