Healthcare costs of congenital cytomegalovirus (cCMV) disease in infants during the first two years of life: a retrospective German claims database analysis

Congenital cytomegalovirus (cCMV) infection can cause severe neurological damage, growth retardation, hearing loss, and microcephaly in infants. We aimed at assessing healthcare costs of infants with recorded cCMV diagnosis in an administrative claims database in the first 2 years of life. We conduc...

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Bibliographic Details
Published in:Cost effectiveness and resource allocation 2023-01, Vol.21 (1), p.8-8, Article 8
Main Authors: Stephan, Anna-Janina, de Lepper, Marion, Wölle, Regine, Luzak, Agnes, Wang, Wei, Jacob, Christian, Schneider, Kim Maren, Buxmann, Horst, Goelz, Rangmar, Hamprecht, Klaus, Kummer, Peter, Modrow, Susanne, Greiner, Wolfgang, Reuschenbach, Miriam
Format: Article
Language:English
Subjects:
Administrative data
Analysis
Babies
Birth weight
Congenital CMV infection
Congenital diseases
Costs
Cytomegalovirus
Cytomegalovirus infections
Data analysis
Diseases
Economic aspects
Germany
Health care expenditures
Health economic burden
Hearing loss
Infants (Newborn)
Infections
Medical care, Cost of
Mortality
Newborn babies
Newborns
Population
Pregnancy
Womens health
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Summary:Congenital cytomegalovirus (cCMV) infection can cause severe neurological damage, growth retardation, hearing loss, and microcephaly in infants. We aimed at assessing healthcare costs of infants with recorded cCMV diagnosis in an administrative claims database in the first 2 years of life. We conducted a retrospective, controlled cohort study using German claims data from the Institute for Applied Health Research Berlin (InGef) database. Incremental healthcare costs during the first and second year of life were assessed by matching (1:60) infants with cCMV diagnoses ≤ 90 days after birth (cCMV cohort) to infants without cCMV diagnosis ("representative" controls) and infants with cCMV diagnoses ≤ 21 days after birth plus specific symptoms (cCMV ) to infants without cCMV and any ICD-10-GM records (besides Z00-Z99) until 4 preventive health check-up ("healthy" controls). Due to missing data, mean imputation was applied for aids and remedies costs. We identified 54 and 24 infants born 2014-2018 for the cCMV and cCMV cohorts, respectively. During the first year, mean (median) healthcare costs were significantly higher in cCMV cases vs. "representative" controls (€22,737 (€9759) vs. €3091 (€863), p 
ISSN:1478-7547
1478-7547
DOI:10.1186/s12962-022-00411-x