Air Plasma Functionalization of Electrospun Nanofibers for Skin Tissue Engineering

Nowadays, gelatin, a molecular derivative of collagen, has gained increasing interest in tissue engineering applications due to excellent biocompatibility, biodegradability, availability, process simplicity, and low costs. In this study, we fabricated tannic acid-crosslinked gelatin nanofibers by el...

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Bibliographic Details
Published in:Biomedicines 2022-03, Vol.10 (3), p.617
Main Authors: Mozaffari, Abolfazl, Parvinzadeh Gashti, Mazeyar
Format: Article
Language:English
Subjects:
Acids
Analytical chemistry
Atomic force microscopy
Biocompatibility
Biodegradability
Biomedical materials
Cell culture
Collagen
Contact angle
electrospinning
Fibroblasts
Fourier transforms
Gelatin
Morphology
nanofibers
Plasma
Polymers
Scanning electron microscopy
Skin
skin tissue engineering
Spectrum analysis
Tannic acid
Tissue engineering
Topography
X-ray diffraction
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Summary:Nowadays, gelatin, a molecular derivative of collagen, has gained increasing interest in tissue engineering applications due to excellent biocompatibility, biodegradability, availability, process simplicity, and low costs. In this study, we fabricated tannic acid-crosslinked gelatin nanofibers by electrospinning method. In order to increase the bio-functionality of scaffolds, they were exposed to the atmospheric air plasma. Several analytical tools were used for evaluation of nanofibers including scanning electron microscopy (SEM), atomic force microscopy (AFM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, X-ray diffraction (XRD), and water contact angle equipment (CA) together with biocompatibility study using fibroblast cells. Results demonstrated that atmospheric air plasma is not only able to improve the hydrophilicity of nanofibers but it also improves the bio-functionality against human skin fibroblast cells. Hence, we recommend atmospheric air plasma pre-treatment approach for the surface functionalization of gelatin nanofibers for skin tissue engineering applications.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines10030617