Microglia in Multiple Sclerosis: Friend or Foe?

Microglia originate from myeloid progenitors in the embryonic yolk sac and play an integral role in central nervous system (CNS) development, immune surveillance and repair. The role of microglia in multiple sclerosis (MS) has been complex and controversial, with evidence suggesting that these cells...

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Bibliographic Details
Published in:Frontiers in immunology 2020-03, Vol.11, p.374-374
Main Authors: Guerrero, Brooke L, Sicotte, Nancy L
Format: Article
Language:English
Subjects:
Antirheumatic Agents - therapeutic use
Biomarkers
Demyelinating Diseases - diagnosis
Demyelinating Diseases - immunology
Demyelinating Diseases - pathology
Genetic Diseases, Inborn - immunology
Humans
Immunologic Surveillance
Immunology
Macrophages - immunology
microglia
Microglia - drug effects
Microglia - immunology
multiple sclerosis
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - drug therapy
Multiple Sclerosis - immunology
Multiple Sclerosis - pathology
Neurodegenerative Diseases - immunology
Neurodegenerative Diseases - pathology
Neuroimaging - methods
pathology
PET imaging
quantitative susceptibility mapping
T-Lymphocyte Subsets - immunology
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Summary:Microglia originate from myeloid progenitors in the embryonic yolk sac and play an integral role in central nervous system (CNS) development, immune surveillance and repair. The role of microglia in multiple sclerosis (MS) has been complex and controversial, with evidence suggesting that these cells play key roles in both active inflammation and remyelination. Here we will review the most recent histological classification of MS lesions as well as the evidence supporting both inflammatory and reparative functions of these cells. We will also review how microglia may yield new biomarkers for MS activity and serve as a potential target for therapy.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.00374