Role of the Inflammasome, IL-1β, and IL-18 in Bacterial Infections

The inflammasome is an important innate immune pathway that regulates at least two host responses protective against infections: (1) secretion of the proinflammatory cytokines IL-1β and IL-18 and (2) induction of pyroptosis, a form of cell death. Inflammasomes, of which different types have been ide...

Full description

Saved in:
Bibliographic Details
Published in:TheScientificWorld 2011-01, Vol.2011 (2011), p.1-14
Main Authors: Re, Fabio, del Barrio, Laura, Ceballos-Olvera, Ivonne, Sahoo, Manoranjan
Format: Article
Language:English
Subjects:
Bacterial infections
Bacterial Infections - immunology
Cell death
Development and progression
Health aspects
Humans
Inflammasomes - physiology
Interleukin-18 - immunology
Interleukin-18 - physiology
Interleukin-1beta - immunology
Interleukin-1beta - physiology
Interleukins
Physiological aspects
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c533t-7e235f2d006daf9b63f1effd6e8eacd09d44ba7869d99650185cc5ce651a745a3
cites cdi_FETCH-LOGICAL-c533t-7e235f2d006daf9b63f1effd6e8eacd09d44ba7869d99650185cc5ce651a745a3
container_end_page 14
container_issue 2011
container_start_page 1
container_title TheScientificWorld
container_volume 2011
creator Re, Fabio
del Barrio, Laura
Ceballos-Olvera, Ivonne
Sahoo, Manoranjan
description The inflammasome is an important innate immune pathway that regulates at least two host responses protective against infections: (1) secretion of the proinflammatory cytokines IL-1β and IL-18 and (2) induction of pyroptosis, a form of cell death. Inflammasomes, of which different types have been identified, are multiprotein complexes containing pattern recognition receptors belonging to the Nod-like receptor family or the PYHIN family and the protease caspase-1. The molecular aspects involved in the activation of different inflammasomes by various pathogens are being rapidly elucidated, and their role during infections is being characterized. Production of IL-1β and IL-18 and induction of pyroptosis of the infected cell have been shown to be protective against many infectious agents. Here, we review the recent literature concerning inflammasome activation in the context of bacterial infections and identify important questions to be answered in the future.
doi_str_mv 10.1100/2011/212680
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_559dd3c533a1417889decc28b8e65534</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A290112693</galeid><doaj_id>oai_doaj_org_article_559dd3c533a1417889decc28b8e65534</doaj_id><sourcerecordid>A290112693</sourcerecordid><originalsourceid>FETCH-LOGICAL-c533t-7e235f2d006daf9b63f1effd6e8eacd09d44ba7869d99650185cc5ce651a745a3</originalsourceid><addsrcrecordid>eNqFkl2LEzEUhgdR3Lp65bUy4IWgO7vJ5GOSG2G3-FEoCKLgXThNTtosM8k6M1X8W_tD_E2mnbVYECQXCSdPnpyQtyieUnJOKSEXNaH0oqa1VOReMaOCNVXD-df7xaxmQlaScnJSPBqGa0KYaqh4WJzUGRdc8Fkx_5RaLJMvxw2Wi-hb6DoYUodn5WJZ0V-3ZyVEt1-rMsTyCuyIfYB2B6MdQ4rD4-KBh3bAJ3fzafHl3dvP8w_V8uP7xfxyWVnB2Fg1mPvxtSNEOvB6JZmn6L2TqBCsI9pxvoJGSe20loJQJawVFqWg0HAB7LRYTF6X4Nrc9KGD_qdJEMy-kPq1gX4MtkUjhHaO7e4FymmjlHZoba1WKusE49n1ZnLdbFcdOotx7KE9kh7vxLAx6_TdsJo2QukseHkn6NO3LQ6j6cJgsW0hYtoORpOGMMI1y-SLiVxD7ixEn7LQ7mhzWev8ebXcU-f_oPJw2AWbIvqQ60cHXk8HbJ-GoUd_aJ4SswuG2QXDTMHI9PO_33tg_yQhA68mYBOigx_hP7ZnE4wZQQ8HWOusk-w31c3GGg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>907030493</pqid></control><display><type>article</type><title>Role of the Inflammasome, IL-1β, and IL-18 in Bacterial Infections</title><source>Wiley Online Library Open Access</source><source>PubMed Central</source><creator>Re, Fabio ; del Barrio, Laura ; Ceballos-Olvera, Ivonne ; Sahoo, Manoranjan</creator><contributor>Fantuzzi, Giamila</contributor><creatorcontrib>Re, Fabio ; del Barrio, Laura ; Ceballos-Olvera, Ivonne ; Sahoo, Manoranjan ; Fantuzzi, Giamila</creatorcontrib><description>The inflammasome is an important innate immune pathway that regulates at least two host responses protective against infections: (1) secretion of the proinflammatory cytokines IL-1β and IL-18 and (2) induction of pyroptosis, a form of cell death. Inflammasomes, of which different types have been identified, are multiprotein complexes containing pattern recognition receptors belonging to the Nod-like receptor family or the PYHIN family and the protease caspase-1. The molecular aspects involved in the activation of different inflammasomes by various pathogens are being rapidly elucidated, and their role during infections is being characterized. Production of IL-1β and IL-18 and induction of pyroptosis of the infected cell have been shown to be protective against many infectious agents. Here, we review the recent literature concerning inflammasome activation in the context of bacterial infections and identify important questions to be answered in the future.</description><identifier>ISSN: 2356-6140</identifier><identifier>ISSN: 1537-744X</identifier><identifier>EISSN: 1537-744X</identifier><identifier>DOI: 10.1100/2011/212680</identifier><identifier>PMID: 22125454</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Bacterial infections ; Bacterial Infections - immunology ; Cell death ; Development and progression ; Health aspects ; Humans ; Inflammasomes - physiology ; Interleukin-18 - immunology ; Interleukin-18 - physiology ; Interleukin-1beta - immunology ; Interleukin-1beta - physiology ; Interleukins ; Physiological aspects ; Review</subject><ispartof>TheScientificWorld, 2011-01, Vol.2011 (2011), p.1-14</ispartof><rights>Copyright © 2011 Manoranjan Sahoo et al.</rights><rights>COPYRIGHT 2011 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2011 Manoranjan Sahoo et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-7e235f2d006daf9b63f1effd6e8eacd09d44ba7869d99650185cc5ce651a745a3</citedby><cites>FETCH-LOGICAL-c533t-7e235f2d006daf9b63f1effd6e8eacd09d44ba7869d99650185cc5ce651a745a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217589/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217589/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22125454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Fantuzzi, Giamila</contributor><creatorcontrib>Re, Fabio</creatorcontrib><creatorcontrib>del Barrio, Laura</creatorcontrib><creatorcontrib>Ceballos-Olvera, Ivonne</creatorcontrib><creatorcontrib>Sahoo, Manoranjan</creatorcontrib><title>Role of the Inflammasome, IL-1β, and IL-18 in Bacterial Infections</title><title>TheScientificWorld</title><addtitle>ScientificWorldJournal</addtitle><description>The inflammasome is an important innate immune pathway that regulates at least two host responses protective against infections: (1) secretion of the proinflammatory cytokines IL-1β and IL-18 and (2) induction of pyroptosis, a form of cell death. Inflammasomes, of which different types have been identified, are multiprotein complexes containing pattern recognition receptors belonging to the Nod-like receptor family or the PYHIN family and the protease caspase-1. The molecular aspects involved in the activation of different inflammasomes by various pathogens are being rapidly elucidated, and their role during infections is being characterized. Production of IL-1β and IL-18 and induction of pyroptosis of the infected cell have been shown to be protective against many infectious agents. Here, we review the recent literature concerning inflammasome activation in the context of bacterial infections and identify important questions to be answered in the future.</description><subject>Bacterial infections</subject><subject>Bacterial Infections - immunology</subject><subject>Cell death</subject><subject>Development and progression</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Inflammasomes - physiology</subject><subject>Interleukin-18 - immunology</subject><subject>Interleukin-18 - physiology</subject><subject>Interleukin-1beta - immunology</subject><subject>Interleukin-1beta - physiology</subject><subject>Interleukins</subject><subject>Physiological aspects</subject><subject>Review</subject><issn>2356-6140</issn><issn>1537-744X</issn><issn>1537-744X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNqFkl2LEzEUhgdR3Lp65bUy4IWgO7vJ5GOSG2G3-FEoCKLgXThNTtosM8k6M1X8W_tD_E2mnbVYECQXCSdPnpyQtyieUnJOKSEXNaH0oqa1VOReMaOCNVXD-df7xaxmQlaScnJSPBqGa0KYaqh4WJzUGRdc8Fkx_5RaLJMvxw2Wi-hb6DoYUodn5WJZ0V-3ZyVEt1-rMsTyCuyIfYB2B6MdQ4rD4-KBh3bAJ3fzafHl3dvP8w_V8uP7xfxyWVnB2Fg1mPvxtSNEOvB6JZmn6L2TqBCsI9pxvoJGSe20loJQJawVFqWg0HAB7LRYTF6X4Nrc9KGD_qdJEMy-kPq1gX4MtkUjhHaO7e4FymmjlHZoba1WKusE49n1ZnLdbFcdOotx7KE9kh7vxLAx6_TdsJo2QukseHkn6NO3LQ6j6cJgsW0hYtoORpOGMMI1y-SLiVxD7ixEn7LQ7mhzWev8ebXcU-f_oPJw2AWbIvqQ60cHXk8HbJ-GoUd_aJ4SswuG2QXDTMHI9PO_33tg_yQhA68mYBOigx_hP7ZnE4wZQQ8HWOusk-w31c3GGg</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Re, Fabio</creator><creator>del Barrio, Laura</creator><creator>Ceballos-Olvera, Ivonne</creator><creator>Sahoo, Manoranjan</creator><general>Hindawi Publishing Corporation</general><general>John Wiley &amp; Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20110101</creationdate><title>Role of the Inflammasome, IL-1β, and IL-18 in Bacterial Infections</title><author>Re, Fabio ; del Barrio, Laura ; Ceballos-Olvera, Ivonne ; Sahoo, Manoranjan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-7e235f2d006daf9b63f1effd6e8eacd09d44ba7869d99650185cc5ce651a745a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Bacterial infections</topic><topic>Bacterial Infections - immunology</topic><topic>Cell death</topic><topic>Development and progression</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Inflammasomes - physiology</topic><topic>Interleukin-18 - immunology</topic><topic>Interleukin-18 - physiology</topic><topic>Interleukin-1beta - immunology</topic><topic>Interleukin-1beta - physiology</topic><topic>Interleukins</topic><topic>Physiological aspects</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Re, Fabio</creatorcontrib><creatorcontrib>del Barrio, Laura</creatorcontrib><creatorcontrib>Ceballos-Olvera, Ivonne</creatorcontrib><creatorcontrib>Sahoo, Manoranjan</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>TheScientificWorld</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Re, Fabio</au><au>del Barrio, Laura</au><au>Ceballos-Olvera, Ivonne</au><au>Sahoo, Manoranjan</au><au>Fantuzzi, Giamila</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of the Inflammasome, IL-1β, and IL-18 in Bacterial Infections</atitle><jtitle>TheScientificWorld</jtitle><addtitle>ScientificWorldJournal</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>2011</volume><issue>2011</issue><spage>1</spage><epage>14</epage><pages>1-14</pages><issn>2356-6140</issn><issn>1537-744X</issn><eissn>1537-744X</eissn><abstract>The inflammasome is an important innate immune pathway that regulates at least two host responses protective against infections: (1) secretion of the proinflammatory cytokines IL-1β and IL-18 and (2) induction of pyroptosis, a form of cell death. Inflammasomes, of which different types have been identified, are multiprotein complexes containing pattern recognition receptors belonging to the Nod-like receptor family or the PYHIN family and the protease caspase-1. The molecular aspects involved in the activation of different inflammasomes by various pathogens are being rapidly elucidated, and their role during infections is being characterized. Production of IL-1β and IL-18 and induction of pyroptosis of the infected cell have been shown to be protective against many infectious agents. Here, we review the recent literature concerning inflammasome activation in the context of bacterial infections and identify important questions to be answered in the future.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>22125454</pmid><doi>10.1100/2011/212680</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2356-6140
ispartof TheScientificWorld, 2011-01, Vol.2011 (2011), p.1-14
issn 2356-6140
1537-744X
1537-744X
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_559dd3c533a1417889decc28b8e65534
source Wiley Online Library Open Access; PubMed Central
subjects Bacterial infections
Bacterial Infections - immunology
Cell death
Development and progression
Health aspects
Humans
Inflammasomes - physiology
Interleukin-18 - immunology
Interleukin-18 - physiology
Interleukin-1beta - immunology
Interleukin-1beta - physiology
Interleukins
Physiological aspects
Review
title Role of the Inflammasome, IL-1β, and IL-18 in Bacterial Infections
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T16%3A54%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20the%20Inflammasome,%20IL-1%CE%B2,%20and%20IL-18%20in%20Bacterial%20Infections&rft.jtitle=TheScientificWorld&rft.au=Re,%20Fabio&rft.date=2011-01-01&rft.volume=2011&rft.issue=2011&rft.spage=1&rft.epage=14&rft.pages=1-14&rft.issn=2356-6140&rft.eissn=1537-744X&rft_id=info:doi/10.1100/2011/212680&rft_dat=%3Cgale_doaj_%3EA290112693%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c533t-7e235f2d006daf9b63f1effd6e8eacd09d44ba7869d99650185cc5ce651a745a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=907030493&rft_id=info:pmid/22125454&rft_galeid=A290112693&rfr_iscdi=true