Superficial Calcified Plates Associated to Plaque Erosions in Acute Coronary Syndromes

This study investigates the clinical relevance and therapeutic implications of the OCT identification of intracoronary superficial calcified plates (SCPs) in acute coronary syndromes (ACSs). In 70 consecutive ACS patients (pts), we studied the three main underlying ACS mechanisms: plaque erosion (PE...

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Bibliographic Details
Published in:Life (Basel, Switzerland) Switzerland), 2023-08, Vol.13 (8), p.1732
Main Authors: Onea, Horea-Laurentiu, Spinu, Mihail, Homorodean, Calin, Ober, Mihai Claudiu, Olinic, Maria, Lazar, Florin-Leontin, Achim, Alexandru, Tataru, Dan Alexandru, Olinic, Dan Mircea
Format: Article
Language:English
Subjects:
Acute coronary syndrome
Acute coronary syndromes
Angina pectoris
Atherosclerosis
atherosclerotic coronary disease
Atherosclerotic plaque
Blood clots
Calcification
Care and treatment
Complications and side effects
culprit lesions
Diagnosis
Disorders
Heart attacks
Lesions
Lipids
Medical imaging
Morphology
optical coherence tomography
Patients
plaque erosion
Plates
Risk factors
Substrates
superficial calcified plates
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Summary:This study investigates the clinical relevance and therapeutic implications of the OCT identification of intracoronary superficial calcified plates (SCPs) in acute coronary syndromes (ACSs). In 70 consecutive ACS patients (pts), we studied the three main underlying ACS mechanisms: plaque erosion (PE), plaque rupture and eruptive calcified nodule (CN). The PE lesions, occurring on an intact fibrous cap overlying a heterogeneous substrate, were identified in 12/70 pts (17.1%). PE on superficial calcified plates (PE-SCP) represented 58.3% of the PE lesions (7/12 pts) and had a 10% overall incidence in the culprit lesions (7/70 pts). PE-SCP lesions occurred mostly on the left anterior descending artery, correlated with white thrombi (85.7%) and had a proximal intraplaque site (71.4%). PE-SCP lesions were treated conservatively, as nonsignificant lesions, in 4/7 pts. Our study emphasizes that the coronary calcium-related ACS risk is not only associated with the spotty calcifications or CN but also with the PE-SCP lesions.
ISSN:2075-1729
2075-1729
DOI:10.3390/life13081732