Comparative Evaluation of 2 Different Percutaneous Techniques of Simultaneous Needle Biopsy With Microwave Ablation of Suspected Malignant Pulmonary Nodules

• Published in: Technology in cancer research & treatment 2023-01, Vol.22, p.15330338231168458-15330338231168458
• Main Authors: Hu, Miaomiao, Wu, Linlin, Zhang, Xusheng, Yuan, Qianqian, Li, Peishun, Yang, Sen, Wang, Baohu, Zhang, Kaixian
• Format: Article
• Language: English
• Subjects: Ablation; Biopsy; Biopsy, Needle - methods; Computed tomography; Embolism; Hemoptysis; Humans; Lung Neoplasms - diagnosis; Lung Neoplasms - radiotherapy; Lung Neoplasms - surgery; Lung nodules; Metastases; Microwave ablation; Microwaves - therapeutic use; Multiple Pulmonary Nodules - surgery; Original; Patients; Pneumothorax; Pneumothorax - etiology; Pneumothorax - therapy; Retrospective Studies; Statistical analysis; Tomography
• ISSN: 1533-0346; 1533-0338
• DOI: 10.1177/15330338231168458

Background: To compare the safety and efficacy of 2 different computed tomography-guided puncture techniques for simultaneous needle biopsy and microwave ablation of suspected malignant pulmonary nodules. Methods: This retrospective comparative before-and-after study analyzed the data of 81 patients (each with a suspected malignant pulmonary nodule) who underwent computed tomography-guided needle biopsy with simultaneous microwave ablation between September 2016 and September 2021. In group A, 41 patients (41 pulmonary nodules) underwent microwave ablation immediately through the biopsy channel, whereas in group B, 40 patients (40 pulmonary nodules) underwent computed tomography-guided percutaneous needle biopsy and microwave ablation through separate needle channels. Clinical data, technical success rates, complications, and short-term efficacy were compared between the groups to evaluate the advantages and disadvantages of both techniques. Results: Of the 81 patients, 78 successfully underwent needle biopsy and microwave ablation, with a technical success rate of 96.3%. The incidence of pneumothorax was 56.1% (23 out of 41) and 30% (12 out of 40) in groups A and B, respectively, while that of chest pain was 34.1% (14 out of 41) and 40% (16 out of 40) in groups A and B, respectively. The differences were statistically insignificant (p = .127 and p = .759). However, the incidence of hemoptysis was 39.0% (16 out of 41) and 17.5% (7 out of 40), respectively, which was statistically significant (P = .015). Air embolism, bronchopleural fistula, and needle implantation metastasis were not observed in both groups. At a 6-month follow-up, there were no other complications in both groups, and complete ablation was observed in all cases. Conclusion: Computed tomography-guided biopsy combined with microwave ablation is safe and effective for the treatment of suspected malignant pulmonary nodules, and clinicians can use both techniques.