Mechanism of lipolysis induced by electrical stimulation of the hypothalamus in the rabbit

Electrical stimulation of the ventro-medial hypothalamus of the rabbit elevated plasma glycerol concentration. This elevation was suppressed by treatments of the animals with hexamethonium and propranolol, or by adrenalectomy, but was not suppressed by treatments with atropine and phentolamine. Thes...

Full description

Saved in:
Bibliographic Details
Published in:Journal of lipid research 1976-11, Vol.17 (6), p.551-558
Main Authors: Kumon, A, Takahashi, A, Hara, T, Shimazu, T
Format: Article
Language:English
Subjects:
adrenalectomy
Animals
Atropine - pharmacology
Blood Glucose - metabolism
Electric Stimulation
Fatty Acids, Nonesterified - blood
Glycerol - blood
hexamethonium
Hydrocortisone - pharmacology
Hypothalamus - drug effects
Hypothalamus - physiology
Kinetics
Lipid Mobilization - drug effects
Male
Phentolamine - pharmacology
plasma glycerol concentration
propranolol
Propranolol - pharmacology
Rabbits
Time Factors
ventro-medial hypothalamus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Electrical stimulation of the ventro-medial hypothalamus of the rabbit elevated plasma glycerol concentration. This elevation was suppressed by treatments of the animals with hexamethonium and propranolol, or by adrenalectomy, but was not suppressed by treatments with atropine and phentolamine. These results would indicate that the effect of electrical stimulation of ventro-medial hypothalamus is mainly mediated by catecholamine(s) liberated from the adrenal medulla and acts on β-receptor of adipose tissue.
ISSN:0022-2275
1539-7262
DOI:10.1016/S0022-2275(20)41725-0