Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: Report of a new case and review of the literature

Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient re...

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Bibliographic Details
Published in:Genetics and molecular biology 2012, Vol.35 (4), p.734-736
Main Authors: Otero, Luize, de Souza, Daiane Correa, de Cássia Tavares, Rita, Gomes, Bernadete Evangelho, Padilha, Telma França, Bouzas, Luiz Fernando, de Souza Fernandez, Teresa, Abdelhay, Eliana
Format: Article
Language:English
Subjects:
BIOCHEMISTRY & MOLECULAR BIOLOGY
bone marrow transplantation
donor cell leukemia
GENETICS & HEREDITY
Human and Medical Genetics
monosomy 7
severe aplastic anemia
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Summary:Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient received a bone marrow graft from his sister, and monosomy 7 was detected only in the XX donor cells, 34 months after transplantation. The patient's bone marrow microenvironment may have played a role in the leukemic transformation of the donor hematopoietic cells.
ISSN:1415-4757
1678-4685
1678-4685
DOI:10.1590/S1415-47572012005000056