Evaluation of the Ankylosing Spondylitis Transcriptome for Oxidative Phosphorylation Pathway: The Shared Pathway with Neurodegenerative Diseases

Ankylosing spondylitis (AS) is a systemic inflammatory disorder of joints and entheses. Recent studies have reported an increased prevalence of dementia in AS patients. However, data for exploring the association between dementia and AS remain uncertain. In this study, enriched pathways and differen...

Full description

Saved in:
Bibliographic Details
Published in:Iranian journal of allergy, asthma, and immunology asthma, and immunology, 2021-09, Vol.20 (5), p.563
Main Authors: Lari, Arezou, Gholami Pourbadie, Hamid, Sharifi-Zarchi, Ali, Aslani, Saeed, Nejatbakhsh Samimi, Leila, Jamshidi, Ahmadreza, Mahmoudi, Mahdi
Format: Article
Language:English
Subjects:
Ankylosing spondylitis
Arthritis
Dementia
Dementia disorders
Gene expression
Gene set enrichment analysis
Inflammatory diseases
Joint diseases
Leukocytes (mononuclear)
Neurodegenerative diseases
Oxidative phosphorylation
Peripheral blood mononuclear cells
Phosphorylation
Transcription
Transcriptomes
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ankylosing spondylitis (AS) is a systemic inflammatory disorder of joints and entheses. Recent studies have reported an increased prevalence of dementia in AS patients. However, data for exploring the association between dementia and AS remain uncertain. In this study, enriched pathways and differentially expressed genes (DEGs) were identified in whole blood transcription data of AS patients obtained from the gene expression omnibus (GEO) database; using gene set enrichment analysis (GSEA) and differential expression analysis. Four pathways, including oxidative phosphorylation, Alzheimer’s, Parkinson’s, and Huntington’s diseases were significantly enriched in AS patients compared to the controls. We identified 22 common genes among the pathways that showed an increasing trend in AS compared to the controls. Five of them including COX7B, NDUFB3, ATP5PF, UQCRB, and NDUFS4 were the most significant genes which were selected for gene expression analysis; using real-time PCR on RNA contents of peripheral blood mononuclear cells (PBMCs) of AS patients and controls (20 samples from each group). The gene expression analysis indicated considerable overexpression of COX7B (p
ISSN:1735-1502
1735-5249
DOI:10.18502/ijaai.v20i5.7406