Left atrial size and risk of recurrent ischemic stroke in cardiogenic cerebral embolism

Background Left atrial enlargement (LAE) was reported to be associated with ischemic stroke and its recurrence. Limited data are available on the relationship of LAE and cardiogenic cerebral embolism (CCE). Our aim is to access the association of left atrial size and the recurrence of ischemic strok...

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Bibliographic Details
Published in:Brain and behavior 2020-10, Vol.10 (10), p.e01798-n/a
Main Authors: Quan, Weiwei, Yang, Xuezhi, Li, Youyu, Li, Jia, Ye, Weiyi, Zhang, Ou, Zhang, Xu
Format: Article
Language:English
Subjects:
cardiogenic cerebral embolism
Diabetes
Embolisms
Hypertension
left atrial size
Normal distribution
Original Research
Patients
recurrent ischemic stroke
Software
Thrombosis
transthoracic echocardiography
Ultrasonic imaging
Veins & arteries
Weiwei Quan is first author
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Summary:Background Left atrial enlargement (LAE) was reported to be associated with ischemic stroke and its recurrence. Limited data are available on the relationship of LAE and cardiogenic cerebral embolism (CCE). Our aim is to access the association of left atrial size and the recurrence of ischemic stroke in CCE. Methods We prospectively included 303 CCE patients who underwent transthoracic echocardiography (TTE). Left atrial size was estimated with left atrial diameter (LAD), diameter/height (LAD/H), and left atrial diameter/body surface area (LAD/BSA). The endpoint was one‐year recurrent ischemic stroke. Cox proportional hazard models were performed to access the association between left atrial size and recurrent ischemic stroke. Results During follow‐up, 27 patients suffered recurrent ischemic stroke. In multivariate COX regression models adjusted for confounders including age, gender, hypertension, diabetes, and history of stroke or transient ischemic attack (TIA), platelet count, fasting blood glucose (FBG), antithrombotic drugs at discharge, stroke volume, and cardiac output, LAD, LAD/H, and LAD/BSA all were independent risk factors of recurrent ischemic stroke [LAD: HR 1.065, 95% CI (1.006–1.128), p = .029; LAD/H: HR 1.157, 95% CI (1.066–1.255), p 
ISSN:2162-3279
2162-3279
DOI:10.1002/brb3.1798