Telomere length and childhood trauma in Colombians with depressive symptoms

Childhood trauma and telomere length (TL) are important risk factors for major depressive disorder. We examined whether there was an association between childhood trauma and TL in a sample of Colombians who were assessed for depressive symptoms. We applied the Center for Epidemiologic Studies Depres...

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Bibliographic Details
Published in:Revista brasileira de psiquiatria 2019-05, Vol.41 (3), p.194-198
Main Authors: Jiménez, Karen M, Pereira-Morales, Angela J, Adan, Ana, Forero, Diego A
Format: Article
Language:English
Subjects:
Childhood trauma
depression
Latin America
Original
PSYCHIATRY
sexual abuse
telomere length
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Summary:Childhood trauma and telomere length (TL) are important risk factors for major depressive disorder. We examined whether there was an association between childhood trauma and TL in a sample of Colombians who were assessed for depressive symptoms. We applied the Center for Epidemiologic Studies Depression scale, the Patient Health Questionnaire-9, the Hospital Anxiety and Depression scale and the Childhood Trauma Questionnaire to 92 Colombian subjects (mean age = 21). TL was measured with quantitative PCR. Spearman's correlation coefficient (rs) was used to analyze the relationship between childhood trauma scores and TL. We found a significant correlation between TL and sexual abuse scores (rs = 0.428, p = 0.002) in individuals with higher depressive symptom scores. This is the first report of a significant association between TL and sexual abuse in a Latin American sample and provides additional evidence about the role of childhood trauma and TL in neuropsychiatric disorders.
ISSN:1516-4446
1809-452X
1809-452X
DOI:10.1590/1516-4446-2018-0027