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The association between adult-type hypolactasia and symptoms of functional dyspepsia

Functional dyspepsia and lactose intolerance (adult-type hypolactasia, ATH) are common conditions that may coexist or even be confounded. Their clinical presentation can be similar, however, lactose intolerance does not form part of the diagnostic investigation of functional dyspepsia. Studies on th...

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Published in:Genetics and molecular biology 2018-01, Vol.41 (1), p.0-97
Main Authors: Wortmann, André Castagna, Simon, Daniel, Mazzoleni, Luiz Edmundo, Sander, Guilherme Becker, Francesconi, Carlos Fernando de Magalhães, Nabinger, Débora Dreher, Grott, Camila Schultz, Rech, Tássia Flores, Mazzoleni, Felipe, Lunge, Vagner Ricardo, Bona, Laura Renata de, Milbradt, Tobias Cancian, Silveira, Themis Reverbel da
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cites cdi_FETCH-LOGICAL-c550t-312ade1b55bebecb8e2d24d313e6e45965dcc6552a4a8a762c0ac985077644973
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container_title Genetics and molecular biology
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creator Wortmann, André Castagna
Simon, Daniel
Mazzoleni, Luiz Edmundo
Sander, Guilherme Becker
Francesconi, Carlos Fernando de Magalhães
Nabinger, Débora Dreher
Grott, Camila Schultz
Rech, Tássia Flores
Mazzoleni, Felipe
Lunge, Vagner Ricardo
Bona, Laura Renata de
Milbradt, Tobias Cancian
Silveira, Themis Reverbel da
description Functional dyspepsia and lactose intolerance (adult-type hypolactasia, ATH) are common conditions that may coexist or even be confounded. Their clinical presentation can be similar, however, lactose intolerance does not form part of the diagnostic investigation of functional dyspepsia. Studies on the association between functional dyspepsia and ATH are scarce. This study aimed to evaluate whether ATH is associated with symptoms of functional dyspepsia. Patients fulfilling the Rome III diagnostic criteria for functional dyspepsia underwent genetic testing for ATH. Dyspeptic symptoms were evaluated and scored according to a validated questionnaire. The diagnostic criteria for ATH was a CC genotype for the -13910C/T polymorphism, located upstream of the lactase gene. The mean scores for dyspeptic symptoms were compared between patients with ATH and those with lactase persistence. A total of 197 functional dyspeptic patients were included in the study. Mean age was 47.7 years and 82.7% patients were women. Eighty-eight patients (44.7%) had a diagnosis of ATH. Abdominal bloating scores were higher in ATH patients compared to the lactase persistent patients (P=0.014). The remaining dyspeptic symptom scores were not significantly different between the two groups. The study results demonstrate an association between ATH and bloating in patients with functional dyspepsia.
doi_str_mv 10.1590/1678-4685-GMB-2017-0015
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Abdominal bloating scores were higher in ATH patients compared to the lactase persistent patients (P=0.014). The remaining dyspeptic symptom scores were not significantly different between the two groups. The study results demonstrate an association between ATH and bloating in patients with functional dyspepsia.</abstract><cop>Brazil</cop><pub>Sociedade Brasileira de Genetica</pub><pmid>29384557</pmid><doi>10.1590/1678-4685-GMB-2017-0015</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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subjects BIOCHEMISTRY & MOLECULAR BIOLOGY
bloating
Diagnostic systems
Dyspepsia
gastrointestinal diseases
Gene polymorphism
Genetic screening
GENETICS & HEREDITY
Human and Medical Genetics
Intolerance
Lactase
Lactose
Lactose intolerance
Polymorphism
single nucleotide polymorphism
title The association between adult-type hypolactasia and symptoms of functional dyspepsia
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