Elevated resting heart rate is associated with mortality in patients with chronic kidney disease

A higher heart rate is recognized as an independent risk factor for all-cause mortality and cardiovascular events in the general population. However, the association between elevated heart rate and clinical adverse outcomes in patients with non-dialysis-dependent chronic kidney disease (CKD) has not...

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Bibliographic Details
Published in:Scientific reports 2024-07, Vol.14 (1), p.17372-8, Article 17372
Main Authors: Saito, Hirotaka, Tanaka, Kenichi, Ejiri, Hiroki, Kimura, Hiroshi, Shimabukuro, Michio, Asahi, Koichi, Watanabe, Tsuyoshi, Kazama, Junichiro James
Format: Article
Language:English
Subjects:
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Cardiovascular diseases
Cardiovascular Diseases - mortality
Cardiovascular Diseases - physiopathology
Cardiovascular event
Chronic kidney disease
Cohort Studies
Dialysis
Female
Health risks
Heart diseases
Heart Rate
Humanities and Social Sciences
Humans
Kidney diseases
Kidneys
Male
Middle Aged
Mortality
multidisciplinary
Proportional Hazards Models
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - mortality
Renal Insufficiency, Chronic - physiopathology
Rest - physiology
Risk Factors
Science
Science (multidisciplinary)
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Summary:A higher heart rate is recognized as an independent risk factor for all-cause mortality and cardiovascular events in the general population. However, the association between elevated heart rate and clinical adverse outcomes in patients with non-dialysis-dependent chronic kidney disease (CKD) has not been sufficiently investigated. A total of 1353 participants enrolled in the Fukushima CKD Cohort Study were examined to investigate associations between resting heart rate and clinical adverse outcomes using Cox proportional hazards analysis. The primary outcome of the present study was all-cause mortality, with cardiovascular events as the secondary outcome. Participants were stratified into four groups based on resting heart rate levels at baseline (heart rate
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-67970-2