Assessment of blood levels of heavy metals including lead and manganese in healthy children living in the Katanga settlement of Kampala, Uganda

• Published in: BMC public health 2018-06, Vol.18 (1), p.717-8, Article 717
• Main Authors: Cusick, Sarah E, Jaramillo, Ericka G, Moody, Emily C, Ssemata, Andrew S, Bitwayi, Doreen, Lund, Troy C, Mupere, Ezekiel
• Format: Article
• Language: English
• Subjects: Africa; Anemia; Antimony; Arsenic; Barium; Blood; Blood levels; Cadmium; Caregivers; Cesium; Children; Children & youth; Chromium; Cobalt; Cooking; Copper; Drinking water; Environment; Environmental aspects; Exposure; Gaging; Garbage; Global positioning systems; GPS; Hazardous materials; Health aspects; Health care; Heavy metals; Hospitals; Households; Iron; Landfills; Lead; Low income groups; Manganese; Medical laboratories; Metal concentrations; Metals; Neurotoxicity; Nickel; Nutrient deficiency; Pediatrics; Pollution sources; Practice; Public health; Questionnaires; Selenium; Surveys; Variance analysis; Waste disposal sites; Water pollution; Zinc
• ISSN: 1471-2458; 1471-2458
• DOI: 10.1186/s12889-018-5589-0

Exposure to environmental heavy metals is common among African children. Although many of these metals are known neurotoxicants, to date, monitoring of this exposure is limited, even in countries such as Uganda that are undergoing rapid industrialization. An assessment of the burden and potential causes of metal exposure is a critical first step in gauging the public health burden of metal exposure and in guiding its elimination. In May 2016, we enrolled 100 children between the ages of 6 and 59 months living in the Katanga urban settlement of Kampala, Uganda. We measured whole blood concentrations of antimony, arsenic, barium, cadmium, cesium, chromium, cobalt, copper, lead, manganese, nickel, selenium, and zinc. Applying reference cutoffs, we identified metals whose prevalence of elevated blood concentrations was > 10%. We also administered an environmental questionnaire to each child's caregiver to assess potential exposures, including source of drinking water, cooking location and fuel, materials used for roof, walls, and floor, and proximity to potential pollution sources such as main roads, garbage landfills, and fuel stations. We compared log-transformed blood metal concentrations by exposure category, using t-test for dichotomous comparisons and ANOVA for comparisons of three categories, using Tukeys test to adjust for multiple comparisons. The prevalence of high blood levels was elevated for six of the metals: antimony (99%), copper (12%), cadmium (17%), cobalt (19.2%), lead (97%), and manganese (36.4%). Higher blood manganese was significantly associated with having cement walls (p = 0.04) or floors (p = 0.04). Cadmium was greater among children who attended school (