Clinical effectiveness and toxicity of second-line irinotecan in advanced gastric and gastroesophageal junction adenocarcinoma: a single-center observational study

Background: Randomized clinical trials showed improved overall survival (OS) of advanced gastroesophageal adenocarcinoma (GEA) patients treated with second-line taxane or irinotecan. However, most data on irinotecan efficacy in this setting come from large Asian trials. We retrospectively analyzed c...

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Published in:Therapeutic advances in medical oncology 2017-04, Vol.9 (4), p.223-233
Main Authors: Ochenduszko, Sebastian, Puskulluoglu, Mirosława, Konopka, Kamil, Fijorek, Kamil, Slowik, Agnieszka Julia, Pędziwiatr, Michał, Budzyński, Andrzej
Format: Article
Language:English
Subjects:
Adenocarcinoma
Anorexia
Cell number
Clinical trials
Diarrhea
Gastric cancer
Immunological tolerance
Irinotecan
Leukopenia
Lymphocytes
Medical prognosis
Metastases
Metastasis
Multivariate analysis
Nausea
Neutropenia
Observational studies
Original Research
Patients
Peritoneum
Toxicity
Vomiting
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Summary:Background: Randomized clinical trials showed improved overall survival (OS) of advanced gastroesophageal adenocarcinoma (GEA) patients treated with second-line taxane or irinotecan. However, most data on irinotecan efficacy in this setting come from large Asian trials. We retrospectively analyzed clinical effectiveness and toxicity of irinotecan in a cohort of patients with advanced GEA treated in our department. Methods: Advanced GEA patients who received at least one cycle of second-line irinotecan were eligible for inclusion. Irinotecan was administered every 3 weeks at an initial dose of 250 mg/m2 of body surface area with subsequent gradual (every 50 mg/m2) dose escalation up to 350 mg/m2, in the case of good treatment tolerance. OS was estimated using the Kaplan–Meier method. A multivariate Cox regression analysis was used to examine the association between clinical and laboratory parameters and survival. Results: A total of 48 patients were identified. Median OS was 6.2 months [95% confidence interval (CI): 3.9–7.6]. In multivariate analysis, age
ISSN:1758-8359
1758-8340
1758-8359
DOI:10.1177/1758834016689029