How to dose follitropin delta for the first insemination cycle according to the ESHRE and ASRM guidelines; a retrospective cohort study

Follitropin Delta (FD) is indicated exclusively for in-vitro fertilization however, being a gonadotropin it could be used for other purposes. A dosing algorithm exists for FD and IVF but is needed for intrauterine insemination (IUI) cycles. The objective of this study is to determine dosing for FD f...

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Bibliographic Details
Published in:Journal of ovarian research 2023-01, Vol.16 (1), p.24-24, Article 24
Main Authors: Arab, Suha, Frank, Russell, Ruiter, Jacob, Dahan, Michael H
Format: Article
Language:English
Subjects:
Algorithms
AMH
Analysis
Body Weight
COH
Cohort analysis
Cysts
Dosage
Drug dosages
Fallopian tubes
Female
Fertility
Fertility clinics
Fertilization
Fertilization in Vitro - methods
Follicle-stimulating hormone
Follicles
Follitropin Delta
Gonadotropin
Gonadotropins
Humans
Immunoassay
Infertility
Insemination
IUI
Menstruation
Methods
Oral administration
Ovarian Hyperstimulation Syndrome
Ovaries
Ovulation
Ovulation Induction - methods
Pathology
Physicians
Pituitary (anterior)
Pregnancy
Pregnancy Rate
Recruitment
Rekovelle
Retrospective Studies
Ultrasonic imaging
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Summary:Follitropin Delta (FD) is indicated exclusively for in-vitro fertilization however, being a gonadotropin it could be used for other purposes. A dosing algorithm exists for FD and IVF but is needed for intrauterine insemination (IUI) cycles. The objective of this study is to determine dosing for FD for the first controlled ovarian hyperstimulation (COH) cycle according to current stimulation guidelines. A retrospective study of 157 subjects from a single university fertility center from January 2017 to March 2020, was performed. All patients stimulated with FD for IUI were included. The number of failed, normal, or overstimulation cycles was determined based on stimulating not more than 2 mature follicles. We then stratified the group based on the AFC, AMH, and body weight. Of 157 subjects, 49% stimulated correctly, 5.6% failed and 45.4% overstimulated. An analysis of the COH IUI cycles based on stratification and over or lack of stimulation per published guidelines found that women with a bodyweight 
ISSN:1757-2215
1757-2215
DOI:10.1186/s13048-022-01079-w