New spectrophotometric method for the determination of gabapentin in bulk and dosage forms using p-dimethylaminobenzaldehyde

A new simple, accurate and economic spectrophotometric method based on azo dye derivatization for the determination of gabapentin (GBP) was developed. Critical factors were optimized. The method was validated and assay of dosage forms was done. Spot tests and TLC confirmed the formation of azo adduc...

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Bibliographic Details
Published in:Journal of Taibah University for Science 2018-11, Vol.12 (6), p.754-764
Main Authors: Adegoke, Olajire A., Adegbolagun, Olayemi M., Aiyenale, Elizabeth O., Thomas, Olusegun E.
Format: Article
Language:English
Subjects:
diazo coupling reaction
Gabapentin
p-dimethylaminobenz aldehyde
spectrophotometric determination
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Summary:A new simple, accurate and economic spectrophotometric method based on azo dye derivatization for the determination of gabapentin (GBP) was developed. Critical factors were optimized. The method was validated and assay of dosage forms was done. Spot tests and TLC confirmed the formation of azo adduct. A 0.3 M NaNO 2 solution using 2 M HCl was used for diazotization. The optimal temperature and time were 30°C and 10 min. Azo adducts were determined at 430 nm. Methanol was found to be the best solvent. Gabapentin coupled at a ratio of 1:1 with DMAB. The assays of GBP were linear over the range 1-6 µg/mL (r = 0.9973) and LOD of 0.8322 µg/mL. The methods were accurate (error 
ISSN:1658-3655
1658-3655
DOI:10.1080/16583655.2018.1495418