MALDI-TOF MS profiling in the discovery and identification of salivary proteomic patterns of temporomandibular joint disorders

This research aimed to identify differences in polypeptide/protein profiles of the unstimulated whole saliva between patients with temporomandibular joint disorders (TMDs) and healthy individuals. A fraction of the polypeptides/proteins (0.8 were selected. A panel of salivary markers that predicted...

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Bibliographic Details
Published in:Open Chemistry 2020-01, Vol.18 (1), p.1173-1180
Main Authors: Laputková, Galina, Talian, Ivan, Schwartzová, Vladimíra, Schwartzová, Zuzana
Format: Article
Language:English
Subjects:
MALDI-TOF MS
proteomics
saliva
temporomandibular joint disorders
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Summary:This research aimed to identify differences in polypeptide/protein profiles of the unstimulated whole saliva between patients with temporomandibular joint disorders (TMDs) and healthy individuals. A fraction of the polypeptides/proteins (0.8 were selected. A panel of salivary markers that predicted the patients with TMDs was selected (2728.0, 4530.2, 5174.2, 5193.3, 6303.4, 6886.7, 8141.7, 8948.7, 10663.2, 10823.7 and 11009.0  ). Although carried out on relatively small datasets, the classification algorithm used in this study allows the differentiation between salivary samples from subjects with TMDs and healthy individuals and confirms the usefulness of a proteomic profiling approach in the monitoring of the disease.
ISSN:2391-5420
2391-5420
DOI:10.1515/chem-2020-0174