Targeting Reactive Carbonyl Species with Natural Sequestering Agents

Reactive carbonyl species generated by the oxidation of polyunsaturated fatty acids and sugars are highly reactive due to their electrophilic nature, and are able to easily react with the nucleophilic sites of proteins as well as DNA causing cellular dysfunction. Levels of reactive carbonyl species...

Full description

Saved in:
Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2016-02, Vol.21 (3), p.280-280
Main Authors: Hwang, Sung Won, Lee, Yoon-Mi, Aldini, Giancarlo, Yeum, Kyung-Jin
Format: Article
Language:English
Subjects:
bioefficacy
Biological Products - isolation & purification
Biological Products - pharmacology
Chromatography, High Pressure Liquid
Fatty Acids, Unsaturated - chemistry
Glycosides - chemistry
Mass Spectrometry
nanotechniques
Nanotechnology
natural products
Oxidation-Reduction
reactive carbonyl species
Review
Sequestering Agents - isolation & purification
Sequestering Agents - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Reactive carbonyl species generated by the oxidation of polyunsaturated fatty acids and sugars are highly reactive due to their electrophilic nature, and are able to easily react with the nucleophilic sites of proteins as well as DNA causing cellular dysfunction. Levels of reactive carbonyl species and their reaction products have been reported to be elevated in various chronic diseases, including metabolic disorders and neurodegenerative diseases. In an effort to identify sequestering agents for reactive carbonyl species, various analytical techniques such as spectrophotometry, high performance liquid chromatography, western blot, and mass spectrometry have been utilized. In particular, recent advances using a novel high resolution mass spectrometry approach allows screening of complex mixtures such as natural products for their sequestering ability of reactive carbonyl species. To overcome the limited bioavailability and bioefficacy of natural products, new techniques using nanoparticles and nanocarriers may offer a new attractive strategy for increased in vivo utilization and targeted delivery of bioactives.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules21030280