Improvement of genistein content in solid genistein/-cyclodextrin complexes β

Genistein:β-cyclodextrin complexes with high drug loading (19.22%) were prepared by freeze-drying and characterized by differential scanning calorimetry and hydrogen nuclear magnetic resonance spectroscopy. The spatial configuration of the complex was proposed by means of 2D-NOESY experiment combine...

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Bibliographic Details
Published in:Química Nova 2010, Vol.33 (3), p.587-590
Main Authors: Xavier, Clarissa R., Silva, Ana Paula C., Schwingel, Liege C., Borghetti, Greice S., Koester, Letícia S., Mayorga, Paulo, Teixeira, Helder F., Bassani, Valquiria L., Lula, Ivana S., Sinisterra, Rubén D.
Format: Article
Language:English
Subjects:
CHEMISTRY, MULTIDISCIPLINARY
computer molecular mechanics
cyclodextrin
genistein
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Summary:Genistein:β-cyclodextrin complexes with high drug loading (19.22%) were prepared by freeze-drying and characterized by differential scanning calorimetry and hydrogen nuclear magnetic resonance spectroscopy. The spatial configuration of the complex was proposed by means of 2D-NOESY experiment combined with molecular modeling. According to the results obtained, the interaction of genistein with β -cyclodextrin in a 1:1 complex is supposed to occur mainly through the insertion of the guest A-ring in cyclodextrin cavity, without rule out the possibility of inclusion through the B-ring, as previously reported in the literature.
ISSN:0100-4042
1678-7064
1678-7064
DOI:10.1590/S0100-40422010000300019