Improvement of genistein content in solid genistein/-cyclodextrin complexes β

Genistein:β-cyclodextrin complexes with high drug loading (19.22%) were prepared by freeze-drying and characterized by differential scanning calorimetry and hydrogen nuclear magnetic resonance spectroscopy. The spatial configuration of the complex was proposed by means of 2D-NOESY experiment combine...

Full description

Saved in:
Bibliographic Details
Published in:Química Nova 2010, Vol.33 (3), p.587-590
Main Authors: Xavier, Clarissa R., Silva, Ana Paula C., Schwingel, Liege C., Borghetti, Greice S., Koester, Letícia S., Mayorga, Paulo, Teixeira, Helder F., Bassani, Valquiria L., Lula, Ivana S., Sinisterra, Rubén D.
Format: Article
Language:English
Subjects:
CHEMISTRY, MULTIDISCIPLINARY
computer molecular mechanics
cyclodextrin
genistein
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c2569-611bcb90ac444196fce022c211557421c88346a3672087df835e85bd4ab150d73
cites
container_end_page 590
container_issue 3
container_start_page 587
container_title Química Nova
container_volume 33
creator Xavier, Clarissa R.
Silva, Ana Paula C.
Schwingel, Liege C.
Borghetti, Greice S.
Koester, Letícia S.
Mayorga, Paulo
Teixeira, Helder F.
Bassani, Valquiria L.
Lula, Ivana S.
Sinisterra, Rubén D.
description Genistein:β-cyclodextrin complexes with high drug loading (19.22%) were prepared by freeze-drying and characterized by differential scanning calorimetry and hydrogen nuclear magnetic resonance spectroscopy. The spatial configuration of the complex was proposed by means of 2D-NOESY experiment combined with molecular modeling. According to the results obtained, the interaction of genistein with β -cyclodextrin in a 1:1 complex is supposed to occur mainly through the insertion of the guest A-ring in cyclodextrin cavity, without rule out the possibility of inclusion through the B-ring, as previously reported in the literature.
doi_str_mv 10.1590/S0100-40422010000300019
format article
fullrecord <record><control><sourceid>scielo_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_563b97f8999c442eba6bf778e1f40c7f</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><scielo_id>S0100_40422010000300019</scielo_id><doaj_id>oai_doaj_org_article_563b97f8999c442eba6bf778e1f40c7f</doaj_id><sourcerecordid>S0100_40422010000300019</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2569-611bcb90ac444196fce022c211557421c88346a3672087df835e85bd4ab150d73</originalsourceid><addsrcrecordid>eNp1UUtOwzAQtRBIlMIZyAXSjh1_l6jiU6kqC2BtOY5dpUriyg6ovRYH4UykLSoLxGI0ozfz3jzNIHSLYYKZgukLYICcAiVkXwEUQ2B1hkaYC5kL4PQcjU5Dl-gqpTUAEYVgI7Sct5sYPlzruj4LPlu5rk69q7vMhq7fg0OZQlNXv61pbne2CZXb9vEw2G4at3Up-_q8RhfeNMnd_OQxenu4f5095Yvnx_nsbpFbwrjKOcalLRUYSynFinvrgBBLMGZMUIKtlAXlpuCCgBSVlwVzkpUVNSVmUIlijOZH3SqYtd7EujVxp4Op9QEIcaVN7GvbOM14USrhpVJq2EZcaXjphZAOewpW-EFrctRKtnZN0OvwHrvBvD5cVv-57EAQR4KNIaXo_MkABr3_yb_Mb2UEfEU</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Improvement of genistein content in solid genistein/-cyclodextrin complexes β</title><source>SciELO Brazil</source><creator>Xavier, Clarissa R. ; Silva, Ana Paula C. ; Schwingel, Liege C. ; Borghetti, Greice S. ; Koester, Letícia S. ; Mayorga, Paulo ; Teixeira, Helder F. ; Bassani, Valquiria L. ; Lula, Ivana S. ; Sinisterra, Rubén D.</creator><creatorcontrib>Xavier, Clarissa R. ; Silva, Ana Paula C. ; Schwingel, Liege C. ; Borghetti, Greice S. ; Koester, Letícia S. ; Mayorga, Paulo ; Teixeira, Helder F. ; Bassani, Valquiria L. ; Lula, Ivana S. ; Sinisterra, Rubén D.</creatorcontrib><description>Genistein:β-cyclodextrin complexes with high drug loading (19.22%) were prepared by freeze-drying and characterized by differential scanning calorimetry and hydrogen nuclear magnetic resonance spectroscopy. The spatial configuration of the complex was proposed by means of 2D-NOESY experiment combined with molecular modeling. According to the results obtained, the interaction of genistein with β -cyclodextrin in a 1:1 complex is supposed to occur mainly through the insertion of the guest A-ring in cyclodextrin cavity, without rule out the possibility of inclusion through the B-ring, as previously reported in the literature.</description><identifier>ISSN: 0100-4042</identifier><identifier>ISSN: 1678-7064</identifier><identifier>EISSN: 1678-7064</identifier><identifier>DOI: 10.1590/S0100-40422010000300019</identifier><language>eng</language><publisher>Sociedade Brasileira de Química</publisher><subject>CHEMISTRY, MULTIDISCIPLINARY ; computer molecular mechanics ; cyclodextrin ; genistein</subject><ispartof>Química Nova, 2010, Vol.33 (3), p.587-590</ispartof><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2569-611bcb90ac444196fce022c211557421c88346a3672087df835e85bd4ab150d73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,24150,27924,27925</link.rule.ids></links><search><creatorcontrib>Xavier, Clarissa R.</creatorcontrib><creatorcontrib>Silva, Ana Paula C.</creatorcontrib><creatorcontrib>Schwingel, Liege C.</creatorcontrib><creatorcontrib>Borghetti, Greice S.</creatorcontrib><creatorcontrib>Koester, Letícia S.</creatorcontrib><creatorcontrib>Mayorga, Paulo</creatorcontrib><creatorcontrib>Teixeira, Helder F.</creatorcontrib><creatorcontrib>Bassani, Valquiria L.</creatorcontrib><creatorcontrib>Lula, Ivana S.</creatorcontrib><creatorcontrib>Sinisterra, Rubén D.</creatorcontrib><title>Improvement of genistein content in solid genistein/-cyclodextrin complexes β</title><title>Química Nova</title><addtitle>Quím. Nova</addtitle><description>Genistein:β-cyclodextrin complexes with high drug loading (19.22%) were prepared by freeze-drying and characterized by differential scanning calorimetry and hydrogen nuclear magnetic resonance spectroscopy. The spatial configuration of the complex was proposed by means of 2D-NOESY experiment combined with molecular modeling. According to the results obtained, the interaction of genistein with β -cyclodextrin in a 1:1 complex is supposed to occur mainly through the insertion of the guest A-ring in cyclodextrin cavity, without rule out the possibility of inclusion through the B-ring, as previously reported in the literature.</description><subject>CHEMISTRY, MULTIDISCIPLINARY</subject><subject>computer molecular mechanics</subject><subject>cyclodextrin</subject><subject>genistein</subject><issn>0100-4042</issn><issn>1678-7064</issn><issn>1678-7064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp1UUtOwzAQtRBIlMIZyAXSjh1_l6jiU6kqC2BtOY5dpUriyg6ovRYH4UykLSoLxGI0ozfz3jzNIHSLYYKZgukLYICcAiVkXwEUQ2B1hkaYC5kL4PQcjU5Dl-gqpTUAEYVgI7Sct5sYPlzruj4LPlu5rk69q7vMhq7fg0OZQlNXv61pbne2CZXb9vEw2G4at3Up-_q8RhfeNMnd_OQxenu4f5095Yvnx_nsbpFbwrjKOcalLRUYSynFinvrgBBLMGZMUIKtlAXlpuCCgBSVlwVzkpUVNSVmUIlijOZH3SqYtd7EujVxp4Op9QEIcaVN7GvbOM14USrhpVJq2EZcaXjphZAOewpW-EFrctRKtnZN0OvwHrvBvD5cVv-57EAQR4KNIaXo_MkABr3_yb_Mb2UEfEU</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Xavier, Clarissa R.</creator><creator>Silva, Ana Paula C.</creator><creator>Schwingel, Liege C.</creator><creator>Borghetti, Greice S.</creator><creator>Koester, Letícia S.</creator><creator>Mayorga, Paulo</creator><creator>Teixeira, Helder F.</creator><creator>Bassani, Valquiria L.</creator><creator>Lula, Ivana S.</creator><creator>Sinisterra, Rubén D.</creator><general>Sociedade Brasileira de Química</general><scope>AAYXX</scope><scope>CITATION</scope><scope>GPN</scope><scope>DOA</scope></search><sort><creationdate>2010</creationdate><title>Improvement of genistein content in solid genistein/-cyclodextrin complexes β</title><author>Xavier, Clarissa R. ; Silva, Ana Paula C. ; Schwingel, Liege C. ; Borghetti, Greice S. ; Koester, Letícia S. ; Mayorga, Paulo ; Teixeira, Helder F. ; Bassani, Valquiria L. ; Lula, Ivana S. ; Sinisterra, Rubén D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2569-611bcb90ac444196fce022c211557421c88346a3672087df835e85bd4ab150d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>CHEMISTRY, MULTIDISCIPLINARY</topic><topic>computer molecular mechanics</topic><topic>cyclodextrin</topic><topic>genistein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xavier, Clarissa R.</creatorcontrib><creatorcontrib>Silva, Ana Paula C.</creatorcontrib><creatorcontrib>Schwingel, Liege C.</creatorcontrib><creatorcontrib>Borghetti, Greice S.</creatorcontrib><creatorcontrib>Koester, Letícia S.</creatorcontrib><creatorcontrib>Mayorga, Paulo</creatorcontrib><creatorcontrib>Teixeira, Helder F.</creatorcontrib><creatorcontrib>Bassani, Valquiria L.</creatorcontrib><creatorcontrib>Lula, Ivana S.</creatorcontrib><creatorcontrib>Sinisterra, Rubén D.</creatorcontrib><collection>CrossRef</collection><collection>SciELO</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Química Nova</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xavier, Clarissa R.</au><au>Silva, Ana Paula C.</au><au>Schwingel, Liege C.</au><au>Borghetti, Greice S.</au><au>Koester, Letícia S.</au><au>Mayorga, Paulo</au><au>Teixeira, Helder F.</au><au>Bassani, Valquiria L.</au><au>Lula, Ivana S.</au><au>Sinisterra, Rubén D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improvement of genistein content in solid genistein/-cyclodextrin complexes β</atitle><jtitle>Química Nova</jtitle><addtitle>Quím. Nova</addtitle><date>2010</date><risdate>2010</risdate><volume>33</volume><issue>3</issue><spage>587</spage><epage>590</epage><pages>587-590</pages><issn>0100-4042</issn><issn>1678-7064</issn><eissn>1678-7064</eissn><abstract>Genistein:β-cyclodextrin complexes with high drug loading (19.22%) were prepared by freeze-drying and characterized by differential scanning calorimetry and hydrogen nuclear magnetic resonance spectroscopy. The spatial configuration of the complex was proposed by means of 2D-NOESY experiment combined with molecular modeling. According to the results obtained, the interaction of genistein with β -cyclodextrin in a 1:1 complex is supposed to occur mainly through the insertion of the guest A-ring in cyclodextrin cavity, without rule out the possibility of inclusion through the B-ring, as previously reported in the literature.</abstract><pub>Sociedade Brasileira de Química</pub><doi>10.1590/S0100-40422010000300019</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0100-4042
ispartof Química Nova, 2010, Vol.33 (3), p.587-590
issn 0100-4042
1678-7064
1678-7064
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_563b97f8999c442eba6bf778e1f40c7f
source SciELO Brazil
subjects CHEMISTRY, MULTIDISCIPLINARY
computer molecular mechanics
cyclodextrin
genistein
title Improvement of genistein content in solid genistein/-cyclodextrin complexes β
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T06%3A03%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-scielo_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Improvement%20of%20genistein%20content%20in%20solid%20genistein/-cyclodextrin%20complexes%20%CE%B2&rft.jtitle=Qu%C3%ADmica%20Nova&rft.au=Xavier,%20Clarissa%20R.&rft.date=2010&rft.volume=33&rft.issue=3&rft.spage=587&rft.epage=590&rft.pages=587-590&rft.issn=0100-4042&rft.eissn=1678-7064&rft_id=info:doi/10.1590/S0100-40422010000300019&rft_dat=%3Cscielo_doaj_%3ES0100_40422010000300019%3C/scielo_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c2569-611bcb90ac444196fce022c211557421c88346a3672087df835e85bd4ab150d73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rft_scielo_id=S0100_40422010000300019&rfr_iscdi=true