Harzianic Acid Activity against Staphylococcus aureus and Its Role in Calcium Regulation

is a Gram-positive bacterium, which can be found, as a commensal microorganism, on the skin surface or in the nasal mucosa of the human population. However, may become pathogenic and cause severe infections, especially in hospitalized patients. As an opportunistic pathogen, in fact, interferes with...

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Bibliographic Details
Published in:Toxins 2023-03, Vol.15 (4), p.237
Main Authors: Staropoli, Alessia, Cuomo, Paola, Salvatore, Maria Michela, De Tommaso, Gaetano, Iuliano, Mauro, Andolfi, Anna, Tenore, Gian Carlo, Capparelli, Rosanna, Vinale, Francesco
Format: Article
Language:English
Subjects:
Acids
Antimicrobial agents
Bacteria
Bacterial infections
Calcium
Calcium - metabolism
Calcium homeostasis
Calcium ions
Calcium signalling
Cations
Cells
chelation
Cytotoxicity
Divalent cations
fungi
Gram-positive bacteria
Homeostasis
Human populations
Humans
Keratinocytes
Metabolites
Nasal Mucosa - microbiology
NMR
Nuclear magnetic resonance
Opportunist infection
Pathogens
secondary metabolites
Skin
Spectrometry
Spectrophotometry
Staphylococcal Infections - drug therapy
Staphylococcal Infections - microbiology
Staphylococcus aureus
Staphylococcus aureus - metabolism
Staphylococcus infections
Trichoderma
Virulence
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Summary:is a Gram-positive bacterium, which can be found, as a commensal microorganism, on the skin surface or in the nasal mucosa of the human population. However, may become pathogenic and cause severe infections, especially in hospitalized patients. As an opportunistic pathogen, in fact, interferes with the host Ca signaling, favoring the spread of the infection and tissue destruction. The identification of novel strategies to restore calcium homeostasis and prevent the associated clinical outcomes is an emerging challenge. Here, we investigate whether harzianic acid, a bioactive metabolite derived from fungi of the genus , could control -induced Ca movements. First, we show the capability of harzianic acid to complex calcium divalent cations, using mass spectrometric, potentiometric, spectrophotometric, and nuclear magnetic resonance techniques. Then, we demonstrate that harzianic acid significantly modulates Ca increase in HaCaT (human keratinocytes) cells incubated with . In conclusion, this study suggests harzianic acid as a promising therapeutical alternative against diseases associated with Ca homeostasis alteration.
ISSN:2072-6651
2072-6651
DOI:10.3390/toxins15040237