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Harzianic Acid Activity against Staphylococcus aureus and Its Role in Calcium Regulation
is a Gram-positive bacterium, which can be found, as a commensal microorganism, on the skin surface or in the nasal mucosa of the human population. However, may become pathogenic and cause severe infections, especially in hospitalized patients. As an opportunistic pathogen, in fact, interferes with...
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| Published in: | Toxins 2023-03, Vol.15 (4), p.237 |
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| container_issue | 4 |
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| container_title | Toxins |
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| creator | Staropoli, Alessia Cuomo, Paola Salvatore, Maria Michela De Tommaso, Gaetano Iuliano, Mauro Andolfi, Anna Tenore, Gian Carlo Capparelli, Rosanna Vinale, Francesco |
| description | is a Gram-positive bacterium, which can be found, as a commensal microorganism, on the skin surface or in the nasal mucosa of the human population. However,
may become pathogenic and cause severe infections, especially in hospitalized patients. As an opportunistic pathogen, in fact,
interferes with the host Ca
signaling, favoring the spread of the infection and tissue destruction. The identification of novel strategies to restore calcium homeostasis and prevent the associated clinical outcomes is an emerging challenge. Here, we investigate whether harzianic acid, a bioactive metabolite derived from fungi of the genus
, could control
-induced Ca
movements. First, we show the capability of harzianic acid to complex calcium divalent cations, using mass spectrometric, potentiometric, spectrophotometric, and nuclear magnetic resonance techniques. Then, we demonstrate that harzianic acid significantly modulates Ca
increase in HaCaT (human keratinocytes) cells incubated with
. In conclusion, this study suggests harzianic acid as a promising therapeutical alternative against diseases associated with Ca
homeostasis alteration. |
| doi_str_mv | 10.3390/toxins15040237 |
| format | article |
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may become pathogenic and cause severe infections, especially in hospitalized patients. As an opportunistic pathogen, in fact,
interferes with the host Ca
signaling, favoring the spread of the infection and tissue destruction. The identification of novel strategies to restore calcium homeostasis and prevent the associated clinical outcomes is an emerging challenge. Here, we investigate whether harzianic acid, a bioactive metabolite derived from fungi of the genus
, could control
-induced Ca
movements. First, we show the capability of harzianic acid to complex calcium divalent cations, using mass spectrometric, potentiometric, spectrophotometric, and nuclear magnetic resonance techniques. Then, we demonstrate that harzianic acid significantly modulates Ca
increase in HaCaT (human keratinocytes) cells incubated with
. In conclusion, this study suggests harzianic acid as a promising therapeutical alternative against diseases associated with Ca
homeostasis alteration.</description><identifier>ISSN: 2072-6651</identifier><identifier>EISSN: 2072-6651</identifier><identifier>DOI: 10.3390/toxins15040237</identifier><identifier>PMID: 37104175</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acids ; Antimicrobial agents ; Bacteria ; Bacterial infections ; Calcium ; Calcium - metabolism ; Calcium homeostasis ; Calcium ions ; Calcium signalling ; Cations ; Cells ; chelation ; Cytotoxicity ; Divalent cations ; fungi ; Gram-positive bacteria ; Homeostasis ; Human populations ; Humans ; Keratinocytes ; Metabolites ; Nasal Mucosa - microbiology ; NMR ; Nuclear magnetic resonance ; Opportunist infection ; Pathogens ; secondary metabolites ; Skin ; Spectrometry ; Spectrophotometry ; Staphylococcal Infections - drug therapy ; Staphylococcal Infections - microbiology ; Staphylococcus aureus ; Staphylococcus aureus - metabolism ; Staphylococcus infections ; Trichoderma ; Virulence</subject><ispartof>Toxins, 2023-03, Vol.15 (4), p.237</ispartof><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-3a4d1bb4c21f3c9f74e491145f74dba7d1f0d4746173cd34fe76252466272613</citedby><cites>FETCH-LOGICAL-c485t-3a4d1bb4c21f3c9f74e491145f74dba7d1f0d4746173cd34fe76252466272613</cites><orcidid>0000-0002-5090-8127 ; 0000-0003-4504-1714 ; 0000-0002-8946-1609 ; 0000-0001-8949-3654 ; 0000-0001-7367-651X ; 0000-0001-8318-3065 ; 0000-0002-0251-9936</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2806640534/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2806640534?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37104175$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Staropoli, Alessia</creatorcontrib><creatorcontrib>Cuomo, Paola</creatorcontrib><creatorcontrib>Salvatore, Maria Michela</creatorcontrib><creatorcontrib>De Tommaso, Gaetano</creatorcontrib><creatorcontrib>Iuliano, Mauro</creatorcontrib><creatorcontrib>Andolfi, Anna</creatorcontrib><creatorcontrib>Tenore, Gian Carlo</creatorcontrib><creatorcontrib>Capparelli, Rosanna</creatorcontrib><creatorcontrib>Vinale, Francesco</creatorcontrib><title>Harzianic Acid Activity against Staphylococcus aureus and Its Role in Calcium Regulation</title><title>Toxins</title><addtitle>Toxins (Basel)</addtitle><description>is a Gram-positive bacterium, which can be found, as a commensal microorganism, on the skin surface or in the nasal mucosa of the human population. However,
may become pathogenic and cause severe infections, especially in hospitalized patients. As an opportunistic pathogen, in fact,
interferes with the host Ca
signaling, favoring the spread of the infection and tissue destruction. The identification of novel strategies to restore calcium homeostasis and prevent the associated clinical outcomes is an emerging challenge. Here, we investigate whether harzianic acid, a bioactive metabolite derived from fungi of the genus
, could control
-induced Ca
movements. First, we show the capability of harzianic acid to complex calcium divalent cations, using mass spectrometric, potentiometric, spectrophotometric, and nuclear magnetic resonance techniques. Then, we demonstrate that harzianic acid significantly modulates Ca
increase in HaCaT (human keratinocytes) cells incubated with
. In conclusion, this study suggests harzianic acid as a promising therapeutical alternative against diseases associated with Ca
homeostasis alteration.</description><subject>Acids</subject><subject>Antimicrobial agents</subject><subject>Bacteria</subject><subject>Bacterial infections</subject><subject>Calcium</subject><subject>Calcium - metabolism</subject><subject>Calcium homeostasis</subject><subject>Calcium ions</subject><subject>Calcium signalling</subject><subject>Cations</subject><subject>Cells</subject><subject>chelation</subject><subject>Cytotoxicity</subject><subject>Divalent cations</subject><subject>fungi</subject><subject>Gram-positive bacteria</subject><subject>Homeostasis</subject><subject>Human populations</subject><subject>Humans</subject><subject>Keratinocytes</subject><subject>Metabolites</subject><subject>Nasal Mucosa - microbiology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Opportunist infection</subject><subject>Pathogens</subject><subject>secondary metabolites</subject><subject>Skin</subject><subject>Spectrometry</subject><subject>Spectrophotometry</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - metabolism</subject><subject>Staphylococcus infections</subject><subject>Trichoderma</subject><subject>Virulence</subject><issn>2072-6651</issn><issn>2072-6651</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkk1rGzEQQJfS0oQk1xzLQi-9OJVWX7unEkzbGAKFNIfcxOxI68isJVfShri_vnKchjg6aAbp6TGSpqrOKblgrCNfc3h0PlFBOGmYelcdN0Q1MykFff8qP6rOUlqRMhijHVUfqyOmKOFUiePq7griXwfeYX2JzpQpuweXtzUsobhz_TvD5n47BgyIU6phinYXvKkXOdU3YbS18_UcRnTTur6xy2mE7II_rT4MMCZ79hxPqtsf32_nV7PrXz8X88vrGfJW5BkDbmjfc2zowLAbFLe8o5SLkpkelKEDMVxxSRVDw_hglWxEw6VsVCMpO6kWe60JsNKb6NYQtzqA008LIS41xOxwtFpIQUSLvUAUHKEFBRy4MoqQVuLQFde3vWsz9Wtr0PocYTyQHu54d6-X4UFTQktBXVsMX54NMfyZbMp67RLacQRvw5R00xLZdUKQHfr5DboKU_TlqZ4oyYlgvFAXewpjSCna4aUaSvSuB_RhD5QDn17f4QX__-PsHwcprTk</recordid><startdate>20230324</startdate><enddate>20230324</enddate><creator>Staropoli, Alessia</creator><creator>Cuomo, Paola</creator><creator>Salvatore, Maria Michela</creator><creator>De Tommaso, Gaetano</creator><creator>Iuliano, Mauro</creator><creator>Andolfi, Anna</creator><creator>Tenore, Gian Carlo</creator><creator>Capparelli, Rosanna</creator><creator>Vinale, Francesco</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T7</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-5090-8127</orcidid><orcidid>https://orcid.org/0000-0003-4504-1714</orcidid><orcidid>https://orcid.org/0000-0002-8946-1609</orcidid><orcidid>https://orcid.org/0000-0001-8949-3654</orcidid><orcidid>https://orcid.org/0000-0001-7367-651X</orcidid><orcidid>https://orcid.org/0000-0001-8318-3065</orcidid><orcidid>https://orcid.org/0000-0002-0251-9936</orcidid></search><sort><creationdate>20230324</creationdate><title>Harzianic Acid Activity against Staphylococcus aureus and Its Role in Calcium Regulation</title><author>Staropoli, Alessia ; Cuomo, Paola ; Salvatore, Maria Michela ; De Tommaso, Gaetano ; Iuliano, Mauro ; Andolfi, Anna ; Tenore, Gian Carlo ; Capparelli, Rosanna ; Vinale, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-3a4d1bb4c21f3c9f74e491145f74dba7d1f0d4746173cd34fe76252466272613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acids</topic><topic>Antimicrobial agents</topic><topic>Bacteria</topic><topic>Bacterial infections</topic><topic>Calcium</topic><topic>Calcium - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Toxins</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Staropoli, Alessia</au><au>Cuomo, Paola</au><au>Salvatore, Maria Michela</au><au>De Tommaso, Gaetano</au><au>Iuliano, Mauro</au><au>Andolfi, Anna</au><au>Tenore, Gian Carlo</au><au>Capparelli, Rosanna</au><au>Vinale, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Harzianic Acid Activity against Staphylococcus aureus and Its Role in Calcium Regulation</atitle><jtitle>Toxins</jtitle><addtitle>Toxins (Basel)</addtitle><date>2023-03-24</date><risdate>2023</risdate><volume>15</volume><issue>4</issue><spage>237</spage><pages>237-</pages><issn>2072-6651</issn><eissn>2072-6651</eissn><abstract>is a Gram-positive bacterium, which can be found, as a commensal microorganism, on the skin surface or in the nasal mucosa of the human population. However,
may become pathogenic and cause severe infections, especially in hospitalized patients. As an opportunistic pathogen, in fact,
interferes with the host Ca
signaling, favoring the spread of the infection and tissue destruction. The identification of novel strategies to restore calcium homeostasis and prevent the associated clinical outcomes is an emerging challenge. Here, we investigate whether harzianic acid, a bioactive metabolite derived from fungi of the genus
, could control
-induced Ca
movements. First, we show the capability of harzianic acid to complex calcium divalent cations, using mass spectrometric, potentiometric, spectrophotometric, and nuclear magnetic resonance techniques. Then, we demonstrate that harzianic acid significantly modulates Ca
increase in HaCaT (human keratinocytes) cells incubated with
. In conclusion, this study suggests harzianic acid as a promising therapeutical alternative against diseases associated with Ca
homeostasis alteration.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37104175</pmid><doi>10.3390/toxins15040237</doi><orcidid>https://orcid.org/0000-0002-5090-8127</orcidid><orcidid>https://orcid.org/0000-0003-4504-1714</orcidid><orcidid>https://orcid.org/0000-0002-8946-1609</orcidid><orcidid>https://orcid.org/0000-0001-8949-3654</orcidid><orcidid>https://orcid.org/0000-0001-7367-651X</orcidid><orcidid>https://orcid.org/0000-0001-8318-3065</orcidid><orcidid>https://orcid.org/0000-0002-0251-9936</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Toxins, 2023-03, Vol.15 (4), p.237 |
| issn | 2072-6651 2072-6651 |
| language | eng |
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| source | Publicly Available Content Database (Proquest) (PQ_SDU_P3); PubMed Central (Open access) |
| subjects | Acids Antimicrobial agents Bacteria Bacterial infections Calcium Calcium - metabolism Calcium homeostasis Calcium ions Calcium signalling Cations Cells chelation Cytotoxicity Divalent cations fungi Gram-positive bacteria Homeostasis Human populations Humans Keratinocytes Metabolites Nasal Mucosa - microbiology NMR Nuclear magnetic resonance Opportunist infection Pathogens secondary metabolites Skin Spectrometry Spectrophotometry Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus aureus - metabolism Staphylococcus infections Trichoderma Virulence |
| title | Harzianic Acid Activity against Staphylococcus aureus and Its Role in Calcium Regulation |
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