Non-polar lipid from greenshell mussel (Perna canaliculus) inhibits osteoclast differentiation

The osteoclast-dependent bone resorption process is a crucial part of the bone regulatory system. The excessive function of osteoclasts can cause diseases of bone, joint, and other tissues such as osteoporosis and osteoarthritis. Greenshell mussel oil (GSM), a good source of long chain omega-3 polyu...

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Bibliographic Details
Published in:Bone Reports 2021-12, Vol.15, p.101132-101132, Article 101132
Main Authors: Siriarchavatana, Parkpoom, Kruger, Marlena C., Miller, Matthew R., Tian, Hong, Wolber, Frances M.
Format: Article
Language:English
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Greenshell mussel
Omega 3 fatty acid
Osteoarthritis
Osteoclasts
Osteoporosis
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Summary:The osteoclast-dependent bone resorption process is a crucial part of the bone regulatory system. The excessive function of osteoclasts can cause diseases of bone, joint, and other tissues such as osteoporosis and osteoarthritis. Greenshell mussel oil (GSM), a good source of long chain omega-3 polyunsaturated fatty acids (LCn-3PUFAs), was fractionated into total lipid, polar lipid, and non-polar lipid components and their anti-osteoclastogenic activity tested in RAW 264.7 cell cultures. Osteoclast differentiation process was achieved after 5 days of incubation with RANKL in 24-well culture plates. Introducing the non-polar lipid fraction into the culture caused a lack of cell differentiation, and a reduction in tartrate-resistant acid phosphatase (TRAP) activity and TRAP cell numbers in a dose-dependent manner (50% reduction at the concentration of 20 μg/mL, p 
ISSN:2352-1872
2352-1872
DOI:10.1016/j.bonr.2021.101132