Lignans from Bursera fagaroides: Chemistry, Pharmacological Effects and Molecular Mechanism. A Current Review

Bursera fagaroides is a medicinal tree endemic to México, it belongs to the Burseraceae family and has proven antitumor activity. Modern research, performed principally with the bark extracts, have indicated that lignans are the main active constituents of B. fagaroides, with a high content of arylt...

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Bibliographic Details
Published in:Life (Basel, Switzerland) Switzerland), 2021-07, Vol.11 (7), p.685
Main Authors: Antúnez-Mojica, Mayra, Romero-Estrada, Antonio, Hurtado-Díaz, Israel, Miranda-Molina, Alfonso, Alvarez, Laura
Format: Article
Language:English
Subjects:
Acids
Animal models
Anticancer properties
Antitumor activity
Antiviral agents
Bark
Biosynthesis
Bursera fagaroides
Cancer therapies
Cell growth
Chemistry
Chromatography
Constituents
Cytotoxicity
Drug resistance
Enzymes
FDA approval
Flowers & plants
In vivo methods and tests
Inflammation
Lignans
Literature reviews
Lymphoma
Metabolites
Molecular modelling
Natural products
NMR
Nomenclature
Nuclear magnetic resonance
Pharmaceutical sciences
Plant extracts
Plant species
Prostate
Public health
Review
Tubulin
Zebrafish
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Summary:Bursera fagaroides is a medicinal tree endemic to México, it belongs to the Burseraceae family and has proven antitumor activity. Modern research, performed principally with the bark extracts, have indicated that lignans are the main active constituents of B. fagaroides, with a high content of aryltetralin, aryldihydronaphtalene, dibenzylbutirolactone, and dibenzylbutane-type lignans as the constituents of the active extracts. In general, lignans from B. fagaroides exhibited potent anti-cancer activity, although antitumor, anti-bacterial, anti-protozoal, anti-inflammatory, and anti-viral properties have also been described. This review covers literature-reported lignans from B. fagaroides, chemical structures, nomenclature, chromatographic techniques of isolation, characterization strategies, and highlights the anti-cancer molecular mechanisms of lignans. Evaluation of the anticancer function of lignans has been extensively investigated since the cytotoxic in vitro results and in vivo assays in mice and zebrafish models to the tubulin molecular recognition by NMR. Also, we discuss the future direction for studying this important plant species and its lignan metabolites.
ISSN:2075-1729
2075-1729
DOI:10.3390/life11070685