Platycodin D inhibits angiogenic vascular mimicry in NSCLC by regulating the eIF4E-mediated RNA methylome

[Display omitted] •The m7G-lncRNAs were identified through whole transcriptome-sequencing of PD and RIP validation.•The anti-VM effect of PD on NSCLC was investigated both in vivo and in vitro.•The synergistic effect was found in combinational use of PD and eIF4E inhibitor on NSCLC via destabilizati...

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Bibliographic Details
Published in:Journal of pharmaceutical analysis 2024-01, Vol.14 (1), p.152-155
Main Authors: Zheng, Shuyu, Xin, Yanlin, Lin, Jiamin, Xie, Zejuan, Cheng, Keyu, Wang, Shanshan, Lu, Wenli, Yang, Hao, Lu, Tianming, Li, Jun, Qi, Ruogu, Guo, Yuanyuan
Format: Article
Language:English
Subjects:
Angiogenesis
Drug dosages
Epidermal growth factor receptors
Genes
Initiation factor eIF-4E
Lung cancer
Mimicry
Non-coding RNA
Non-small cell lung carcinoma
Ribavirin
Short Communication
Small cell lung carcinoma
Vascular endothelial growth factor
Visualization
Writing
Citations: Items that this one cites
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Description
Summary:[Display omitted] •The m7G-lncRNAs were identified through whole transcriptome-sequencing of PD and RIP validation.•The anti-VM effect of PD on NSCLC was investigated both in vivo and in vitro.•The synergistic effect was found in combinational use of PD and eIF4E inhibitor on NSCLC via destabilization of EGFR.
ISSN:2095-1779
2214-0883
DOI:10.1016/j.jpha.2023.10.003