Effects of Androctonus crassicauda (Olivier, 1807) (scorpiones: buthidae) venom on rats: correlation among acetylcholinesterase activities and electrolytes levels

Scorpions can be considered living fossils because they have changed so little during the last 400 million years. They are venomous arthropods of the Arachnida class and regarded as relatives of spiders, ticks and mites. The aim of the present study was to evaluate the toxicity of Androctonus crassi...

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Published in:The journal of venomous animals and toxins including tropical diseases 2007, Vol.13 (1), p.69-81
Main Authors: Ozkan, O., Adiguzel, S., Kar, S., Kurt, M., Yakistiran, S., Cesaretli, Y., Orman, M., Karaer, Z.
Format: Article
Language:English
Subjects:
acetylcholinesterase
Androctonus crassicauda
Arachnida
Araneae
Arthropoda
Buthidae
electrolytes
Ixodidae
scorpion
Scorpiones
TOXICOLOGY
TROPICAL MEDICINE
venom
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container_title The journal of venomous animals and toxins including tropical diseases
container_volume 13
creator Ozkan, O.
Adiguzel, S.
Kar, S.
Kurt, M.
Yakistiran, S.
Cesaretli, Y.
Orman, M.
Karaer, Z.
description Scorpions can be considered living fossils because they have changed so little during the last 400 million years. They are venomous arthropods of the Arachnida class and regarded as relatives of spiders, ticks and mites. The aim of the present study was to evaluate the toxicity of Androctonus crassicauda (Olivier, 1807) venom and its effects on the acetylcholinesterase (AchE) activity and on electrolytes levels in rats. Animals were divided into seven groups of five rats each. Test groups received 250 mu g/kg of venom solution while control group was treated with 200 mu l of physiological saline solution (PSS). Blood samples were collected from the animals on the 1 super(st), 2 super(nd) 4 super(th), 8 super(th), 12 super(th), and 24 super(th) hours after subcutaneous injection of venom. Animals were monitored for 24 hours. Androctonus crassicauda venom significantly reduced AchE activity on the 12 super(th) hour when compared with control group. A statistically negative correlation between Na super(+) and K super(+) (p
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They are venomous arthropods of the Arachnida class and regarded as relatives of spiders, ticks and mites. The aim of the present study was to evaluate the toxicity of Androctonus crassicauda (Olivier, 1807) venom and its effects on the acetylcholinesterase (AchE) activity and on electrolytes levels in rats. Animals were divided into seven groups of five rats each. Test groups received 250 mu g/kg of venom solution while control group was treated with 200 mu l of physiological saline solution (PSS). Blood samples were collected from the animals on the 1 super(st), 2 super(nd) 4 super(th), 8 super(th), 12 super(th), and 24 super(th) hours after subcutaneous injection of venom. Animals were monitored for 24 hours. Androctonus crassicauda venom significantly reduced AchE activity on the 12 super(th) hour when compared with control group. A statistically negative correlation between Na super(+) and K super(+) (p&lt;0.05) and a positive correlation between Na super(+) and CL super(-) (p&lt;0.001) ions levels were observed after the administration of A. crassiccauda venom to rats. We can conclude that the differences in the electrolytes levels are due to acute renal failure, since elimination of toxin occurs primarily via the kidney.</description><identifier>ISSN: 1678-9199</identifier><identifier>EISSN: 1678-9199</identifier><identifier>DOI: 10.1590/S1678-91992007000100005</identifier><language>eng</language><publisher>Centro de Estudos de Venenos e Animais Peçonhentos</publisher><subject>acetylcholinesterase ; Androctonus crassicauda ; Arachnida ; Araneae ; Arthropoda ; Buthidae ; electrolytes ; Ixodidae ; scorpion ; Scorpiones ; TOXICOLOGY ; TROPICAL MEDICINE ; venom</subject><ispartof>The journal of venomous animals and toxins including tropical diseases, 2007, Vol.13 (1), p.69-81</ispartof><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-e5fc183d957a5a35d10313e12efd51b51085a4022dc88ce5095950de0dc5144a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,4024,24150,27923,27924,27925</link.rule.ids></links><search><creatorcontrib>Ozkan, O.</creatorcontrib><creatorcontrib>Adiguzel, S.</creatorcontrib><creatorcontrib>Kar, S.</creatorcontrib><creatorcontrib>Kurt, M.</creatorcontrib><creatorcontrib>Yakistiran, S.</creatorcontrib><creatorcontrib>Cesaretli, Y.</creatorcontrib><creatorcontrib>Orman, M.</creatorcontrib><creatorcontrib>Karaer, Z.</creatorcontrib><title>Effects of Androctonus crassicauda (Olivier, 1807) (scorpiones: buthidae) venom on rats: correlation among acetylcholinesterase activities and electrolytes levels</title><title>The journal of venomous animals and toxins including tropical diseases</title><addtitle>J. Venom. Anim. Toxins incl. Trop. Dis</addtitle><description>Scorpions can be considered living fossils because they have changed so little during the last 400 million years. They are venomous arthropods of the Arachnida class and regarded as relatives of spiders, ticks and mites. The aim of the present study was to evaluate the toxicity of Androctonus crassicauda (Olivier, 1807) venom and its effects on the acetylcholinesterase (AchE) activity and on electrolytes levels in rats. Animals were divided into seven groups of five rats each. Test groups received 250 mu g/kg of venom solution while control group was treated with 200 mu l of physiological saline solution (PSS). Blood samples were collected from the animals on the 1 super(st), 2 super(nd) 4 super(th), 8 super(th), 12 super(th), and 24 super(th) hours after subcutaneous injection of venom. Animals were monitored for 24 hours. Androctonus crassicauda venom significantly reduced AchE activity on the 12 super(th) hour when compared with control group. A statistically negative correlation between Na super(+) and K super(+) (p&lt;0.05) and a positive correlation between Na super(+) and CL super(-) (p&lt;0.001) ions levels were observed after the administration of A. crassiccauda venom to rats. 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1678-9199
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subjects acetylcholinesterase
Androctonus crassicauda
Arachnida
Araneae
Arthropoda
Buthidae
electrolytes
Ixodidae
scorpion
Scorpiones
TOXICOLOGY
TROPICAL MEDICINE
venom
title Effects of Androctonus crassicauda (Olivier, 1807) (scorpiones: buthidae) venom on rats: correlation among acetylcholinesterase activities and electrolytes levels
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