Uptake of Chlorin e6 Photosensitizer by Polystyrene-Diphenyloxazole-Poly(N-Isopropylacrylamide) Hybrid Nanosystem Studied by Electronic Excitation Energy Transfer

• Published in: Nanoscale research letters 2018-05, Vol.13 (1), p.1-7, Article 166
• Main Authors: Losytskyy, M. Yu, Vretik, L. O., Kutsevol, N. V., Nikolaeva, O. A., Yashchuk, V. M.
• Format: Article
• Language: English
• Subjects: Chemistry and Materials Science; Chlorin e6; Conformation; Conformation transition; Crosslinking; Diphenyloxazole; Donors (electronic); Energy transfer; Excitation; Fluorescence; Isopropylacrylamide; Materials Science; Molecular Medicine; Nano Express; Nanochemistry; Nanoparticles; Nanoscale Science and Technology; Nanotechnology; Nanotechnology and Microengineering; PNIPAM; Poly-N-isopropylacrylamide; Polystyrene; Polystyrene resins; Stimuli-responsive materials; Styrene nanoparticles
• ISSN: 1931-7573; 1556-276X
• DOI: 10.1186/s11671-018-2584-4

Polystyrene (PS)-diphenyloxazole (PPO) nanoparticles with attached cross-linked poly-N-isopropylacrylamide (PNIPAM) chains were obtained resulting in PS-PPO-PNIPAM hybrid nanosystems (NS). Fluorescence spectra of chlorin e 6 added to PS-PPO-PNIPAM hybrid NS revealed electronic excitation energy transfer (EEET) from PS matrix and encapsulated PPO to chlorin e 6 . EEET efficiency increased strongly during 1 h after chlorin e 6 addition, indicating that uptake of chlorin e 6 by PNIPAM part of hybrid NS still proceeds during this time. Heating of PS-PPO-PNIPAM-chlorin e 6 NS from 21 to 39 °C results in an enhancement of EEET efficiency; this is consistent with PNIPAM conformation transition that reduces the distance between PS-PPO donors and chlorin e 6 acceptors. Meanwhile, a relatively small part of chlorin e 6 present in the solution is bound by PNIPAM; thus, further studies in this direction are necessary.