Fetuin-a to adiponectin ratio is a sensitive indicator for evaluating metabolic syndrome in the elderly

Fetuin-A and adiponectin present significant associations, supported by recent evidence, with metabolic syndrome (MS) featuring hyperglycemia, central obesity and insulin resistance as the main components, but their biological functions are opposite. The aim of this study was to verify whether fetui...

Full description

Saved in:
Bibliographic Details
Published in:Lipids in health and disease 2020-04, Vol.19 (1), p.61-61, Article 61
Main Authors: Zhou, Zhongwei, Sun, Mingzhong, Jin, Hao, Chen, Hongmei, Ju, Huixiang
Format: Article
Language:English
Subjects:
Adiponectin
Adiponectin - blood
Aged
alpha-2-HS-Glycoprotein - metabolism
Analysis
Blood pressure
Body mass index
Cardiovascular disease
Cholesterol
Diabetes
Elderly
Enzyme-linked immunosorbent assay
Enzymes
Female
Fetuin-a
Fetuin-a/adiponectin ratio
Geriatrics
Humans
Hyperglycemia
Hypertension
Insulin
Insulin resistance
Linear Models
Liver
Male
Metabolic syndrome
Metabolic Syndrome - blood
Middle Aged
Multivariate Analysis
Obesity
Odds Ratio
Older people
Rankings
Regression analysis
Risk Factors
ROC Curve
Sensitivity analysis
Serum levels
Statistical analysis
Statistics, Nonparametric
Studies
Type 2 diabetes
Variables
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fetuin-A and adiponectin present significant associations, supported by recent evidence, with metabolic syndrome (MS) featuring hyperglycemia, central obesity and insulin resistance as the main components, but their biological functions are opposite. The aim of this study was to verify whether fetuin-A/adiponectin ratio (F/A ratio) is a more sensitive indicator for evaluation of MS than either fetuin-A or adiponectin. In this cross-sectional study, 465 elderly subjects were selected from the physical examination database. Serum levels of fetuin-A and adiponectin were measured using an enzyme-linked immunosorbent assay (ELISA) method. Spearman's rank correlation coefficient, linear regression and logistic regression analysis were adopted to estimate the correlations of fetuin-A, adiponectin and F/A ratio with MS and its components, and receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive values of the aforesaid indices. Compared with fetuin-A or adiponectin, F/A ratio was significantly associated with all the components of MS, and this correlation was significant even after adjusting potential confounding factors (P 
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-020-01251-5