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Fetuin-a to adiponectin ratio is a sensitive indicator for evaluating metabolic syndrome in the elderly
Fetuin-A and adiponectin present significant associations, supported by recent evidence, with metabolic syndrome (MS) featuring hyperglycemia, central obesity and insulin resistance as the main components, but their biological functions are opposite. The aim of this study was to verify whether fetui...
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Published in: | Lipids in health and disease 2020-04, Vol.19 (1), p.61-61, Article 61 |
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description | Fetuin-A and adiponectin present significant associations, supported by recent evidence, with metabolic syndrome (MS) featuring hyperglycemia, central obesity and insulin resistance as the main components, but their biological functions are opposite. The aim of this study was to verify whether fetuin-A/adiponectin ratio (F/A ratio) is a more sensitive indicator for evaluation of MS than either fetuin-A or adiponectin.
In this cross-sectional study, 465 elderly subjects were selected from the physical examination database. Serum levels of fetuin-A and adiponectin were measured using an enzyme-linked immunosorbent assay (ELISA) method. Spearman's rank correlation coefficient, linear regression and logistic regression analysis were adopted to estimate the correlations of fetuin-A, adiponectin and F/A ratio with MS and its components, and receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive values of the aforesaid indices.
Compared with fetuin-A or adiponectin, F/A ratio was significantly associated with all the components of MS, and this correlation was significant even after adjusting potential confounding factors (P |
doi_str_mv | 10.1186/s12944-020-01251-5 |
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In this cross-sectional study, 465 elderly subjects were selected from the physical examination database. Serum levels of fetuin-A and adiponectin were measured using an enzyme-linked immunosorbent assay (ELISA) method. Spearman's rank correlation coefficient, linear regression and logistic regression analysis were adopted to estimate the correlations of fetuin-A, adiponectin and F/A ratio with MS and its components, and receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive values of the aforesaid indices.
Compared with fetuin-A or adiponectin, F/A ratio was significantly associated with all the components of MS, and this correlation was significant even after adjusting potential confounding factors (P < 0.05). Logistic regression analysis indicated that F/A ratio presented a stronger correlation with incident MS (adjusted OR: 1.466; 95% CI: 1.189-1.808) than fetuin-A (adjusted OR: 1.100; 95% CI: 1.020-1.186) and adiponectin (adjusted OR: 0.760; 95% CI: 0.664-0.871) alone. ROC analysis revealed that F/A ratio achieved a larger area under curve (AUC) than fetuin-A and adiponectin, with their AUC values of 0.755, 0.709 and 0.708, respectively.
F/A ratio is a more sensitive index for evaluating MS than either fetuin-A or adiponectin in the elderly.</description><identifier>ISSN: 1476-511X</identifier><identifier>EISSN: 1476-511X</identifier><identifier>DOI: 10.1186/s12944-020-01251-5</identifier><identifier>PMID: 32252782</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adiponectin ; Adiponectin - blood ; Aged ; alpha-2-HS-Glycoprotein - metabolism ; Analysis ; Blood pressure ; Body mass index ; Cardiovascular disease ; Cholesterol ; Diabetes ; Elderly ; Enzyme-linked immunosorbent assay ; Enzymes ; Female ; Fetuin-a ; Fetuin-a/adiponectin ratio ; Geriatrics ; Humans ; Hyperglycemia ; Hypertension ; Insulin ; Insulin resistance ; Linear Models ; Liver ; Male ; Metabolic syndrome ; Metabolic Syndrome - blood ; Middle Aged ; Multivariate Analysis ; Obesity ; Odds Ratio ; Older people ; Rankings ; Regression analysis ; Risk Factors ; ROC Curve ; Sensitivity analysis ; Serum levels ; Statistical analysis ; Statistics, Nonparametric ; Studies ; Type 2 diabetes ; Variables</subject><ispartof>Lipids in health and disease, 2020-04, Vol.19 (1), p.61-61, Article 61</ispartof><rights>COPYRIGHT 2020 BioMed Central Ltd.</rights><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c563t-e429a126747e38bc70f9858b00c66776f06dd897eeded46a936317097b97bcf43</citedby><cites>FETCH-LOGICAL-c563t-e429a126747e38bc70f9858b00c66776f06dd897eeded46a936317097b97bcf43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137520/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2391437149?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32252782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Zhongwei</creatorcontrib><creatorcontrib>Sun, Mingzhong</creatorcontrib><creatorcontrib>Jin, Hao</creatorcontrib><creatorcontrib>Chen, Hongmei</creatorcontrib><creatorcontrib>Ju, Huixiang</creatorcontrib><title>Fetuin-a to adiponectin ratio is a sensitive indicator for evaluating metabolic syndrome in the elderly</title><title>Lipids in health and disease</title><addtitle>Lipids Health Dis</addtitle><description>Fetuin-A and adiponectin present significant associations, supported by recent evidence, with metabolic syndrome (MS) featuring hyperglycemia, central obesity and insulin resistance as the main components, but their biological functions are opposite. The aim of this study was to verify whether fetuin-A/adiponectin ratio (F/A ratio) is a more sensitive indicator for evaluation of MS than either fetuin-A or adiponectin.
In this cross-sectional study, 465 elderly subjects were selected from the physical examination database. Serum levels of fetuin-A and adiponectin were measured using an enzyme-linked immunosorbent assay (ELISA) method. Spearman's rank correlation coefficient, linear regression and logistic regression analysis were adopted to estimate the correlations of fetuin-A, adiponectin and F/A ratio with MS and its components, and receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive values of the aforesaid indices.
Compared with fetuin-A or adiponectin, F/A ratio was significantly associated with all the components of MS, and this correlation was significant even after adjusting potential confounding factors (P < 0.05). Logistic regression analysis indicated that F/A ratio presented a stronger correlation with incident MS (adjusted OR: 1.466; 95% CI: 1.189-1.808) than fetuin-A (adjusted OR: 1.100; 95% CI: 1.020-1.186) and adiponectin (adjusted OR: 0.760; 95% CI: 0.664-0.871) alone. ROC analysis revealed that F/A ratio achieved a larger area under curve (AUC) than fetuin-A and adiponectin, with their AUC values of 0.755, 0.709 and 0.708, respectively.
F/A ratio is a more sensitive index for evaluating MS than either fetuin-A or adiponectin in the elderly.</description><subject>Adiponectin</subject><subject>Adiponectin - blood</subject><subject>Aged</subject><subject>alpha-2-HS-Glycoprotein - metabolism</subject><subject>Analysis</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Diabetes</subject><subject>Elderly</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Enzymes</subject><subject>Female</subject><subject>Fetuin-a</subject><subject>Fetuin-a/adiponectin ratio</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Hypertension</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Linear Models</subject><subject>Liver</subject><subject>Male</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - blood</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Obesity</subject><subject>Odds Ratio</subject><subject>Older people</subject><subject>Rankings</subject><subject>Regression analysis</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Sensitivity analysis</subject><subject>Serum levels</subject><subject>Statistical analysis</subject><subject>Statistics, Nonparametric</subject><subject>Studies</subject><subject>Type 2 diabetes</subject><subject>Variables</subject><issn>1476-511X</issn><issn>1476-511X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkl1rHCEUhofS0qRp_0AvitCb3kzqx6jjTSGEpg0EetNC78TRMxuXGd2qs7D_Pm42DbulqCjH57xyjm_TvCf4kpBefM6Eqq5rMcUtJpSTlr9ozkknRcsJ-f3y6HzWvMl5jSsphXjdnDFKOZU9PW9WN1AWH1qDSkTG-U0MYIsPKJniI_IZGZQhZF_8FpAPzltTYkJjXbA101KxsEIzFDPEyVuUd8GlOO9ZVO4BweQgTbu3zavRTBnePe0Xza-brz-vv7d3P77dXl_dtZYLVlroqDKECtlJYP1gJR5Vz_sBYyuElGLEwrleSQAHrhNGMcGIxEoOddqxYxfN7UHXRbPWm-Rnk3Y6Gq8fAzGttEnF2wk0F0YIjpUTQlQpUML2uBudEoRIYYaq9eWgtVmGGZyFUJKZTkRPb4K_16u41ZIwySmuAp-eBFL8s0AuevbZwjSZAHHJmrJeUi6pUhX9-A-6jksKtVWVUqRjknRH1MrUAnwYY33X7kX1laCS0V5RUqnL_1B1OJi9rR88-ho_SaCHBJtizgnG5xoJ1nur6YPVdDWQfrSa5jXpw3F3nlP-eos9AFlTzdI</recordid><startdate>20200406</startdate><enddate>20200406</enddate><creator>Zhou, Zhongwei</creator><creator>Sun, Mingzhong</creator><creator>Jin, Hao</creator><creator>Chen, Hongmei</creator><creator>Ju, Huixiang</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20200406</creationdate><title>Fetuin-a to adiponectin ratio is a sensitive indicator for evaluating metabolic syndrome in the elderly</title><author>Zhou, Zhongwei ; Sun, Mingzhong ; Jin, Hao ; Chen, Hongmei ; Ju, Huixiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c563t-e429a126747e38bc70f9858b00c66776f06dd897eeded46a936317097b97bcf43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adiponectin</topic><topic>Adiponectin - blood</topic><topic>Aged</topic><topic>alpha-2-HS-Glycoprotein - metabolism</topic><topic>Analysis</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Cardiovascular disease</topic><topic>Cholesterol</topic><topic>Diabetes</topic><topic>Elderly</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Enzymes</topic><topic>Female</topic><topic>Fetuin-a</topic><topic>Fetuin-a/adiponectin ratio</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Hypertension</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Linear Models</topic><topic>Liver</topic><topic>Male</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - blood</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Obesity</topic><topic>Odds Ratio</topic><topic>Older people</topic><topic>Rankings</topic><topic>Regression analysis</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><topic>Sensitivity analysis</topic><topic>Serum levels</topic><topic>Statistical analysis</topic><topic>Statistics, Nonparametric</topic><topic>Studies</topic><topic>Type 2 diabetes</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Zhongwei</creatorcontrib><creatorcontrib>Sun, Mingzhong</creatorcontrib><creatorcontrib>Jin, Hao</creatorcontrib><creatorcontrib>Chen, Hongmei</creatorcontrib><creatorcontrib>Ju, Huixiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Lipids in health and disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Zhongwei</au><au>Sun, Mingzhong</au><au>Jin, Hao</au><au>Chen, Hongmei</au><au>Ju, Huixiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fetuin-a to adiponectin ratio is a sensitive indicator for evaluating metabolic syndrome in the elderly</atitle><jtitle>Lipids in health and disease</jtitle><addtitle>Lipids Health Dis</addtitle><date>2020-04-06</date><risdate>2020</risdate><volume>19</volume><issue>1</issue><spage>61</spage><epage>61</epage><pages>61-61</pages><artnum>61</artnum><issn>1476-511X</issn><eissn>1476-511X</eissn><abstract>Fetuin-A and adiponectin present significant associations, supported by recent evidence, with metabolic syndrome (MS) featuring hyperglycemia, central obesity and insulin resistance as the main components, but their biological functions are opposite. The aim of this study was to verify whether fetuin-A/adiponectin ratio (F/A ratio) is a more sensitive indicator for evaluation of MS than either fetuin-A or adiponectin.
In this cross-sectional study, 465 elderly subjects were selected from the physical examination database. Serum levels of fetuin-A and adiponectin were measured using an enzyme-linked immunosorbent assay (ELISA) method. Spearman's rank correlation coefficient, linear regression and logistic regression analysis were adopted to estimate the correlations of fetuin-A, adiponectin and F/A ratio with MS and its components, and receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive values of the aforesaid indices.
Compared with fetuin-A or adiponectin, F/A ratio was significantly associated with all the components of MS, and this correlation was significant even after adjusting potential confounding factors (P < 0.05). Logistic regression analysis indicated that F/A ratio presented a stronger correlation with incident MS (adjusted OR: 1.466; 95% CI: 1.189-1.808) than fetuin-A (adjusted OR: 1.100; 95% CI: 1.020-1.186) and adiponectin (adjusted OR: 0.760; 95% CI: 0.664-0.871) alone. ROC analysis revealed that F/A ratio achieved a larger area under curve (AUC) than fetuin-A and adiponectin, with their AUC values of 0.755, 0.709 and 0.708, respectively.
F/A ratio is a more sensitive index for evaluating MS than either fetuin-A or adiponectin in the elderly.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>32252782</pmid><doi>10.1186/s12944-020-01251-5</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adiponectin Adiponectin - blood Aged alpha-2-HS-Glycoprotein - metabolism Analysis Blood pressure Body mass index Cardiovascular disease Cholesterol Diabetes Elderly Enzyme-linked immunosorbent assay Enzymes Female Fetuin-a Fetuin-a/adiponectin ratio Geriatrics Humans Hyperglycemia Hypertension Insulin Insulin resistance Linear Models Liver Male Metabolic syndrome Metabolic Syndrome - blood Middle Aged Multivariate Analysis Obesity Odds Ratio Older people Rankings Regression analysis Risk Factors ROC Curve Sensitivity analysis Serum levels Statistical analysis Statistics, Nonparametric Studies Type 2 diabetes Variables |
title | Fetuin-a to adiponectin ratio is a sensitive indicator for evaluating metabolic syndrome in the elderly |
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