Breast cancer patients enrolled in the Swiss mammography screening program "donna" demonstrate prolonged survival

• Published in: Breast cancer research : BCR 2024-05, Vol.26 (1), p.84-84, Article 84
• Main Authors: Kuklinski, David, Blum, Marcel, Subelack, Jonas, Geissler, Alexander, Eichenberger, Alena, Morant, Rudolf
• Format: Article
• Language: English
• Subjects: Aged; Breast cancer; Breast Neoplasms - diagnosis; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - epidemiology; Breast Neoplasms - mortality; Breast Neoplasms - pathology; Cancer; Cancer patients; Cancer therapies; Carcinoma; Comparative analysis; Diagnosis; Early Detection of Cancer - methods; Female; Humans; Mammography; Mammography - methods; Mammography screening program; Mass Screening - methods; Mastectomy; Metastases; Metastasis; Middle Aged; Mortality; Neoplasm Staging; Oncology, Experimental; Patient outcomes; Patients; Registries; Survival; Survival Rate; Switzerland; Switzerland - epidemiology; Tumors; Women
• ISSN: 1465-542X; 1465-5411; 1465-542X
• DOI: 10.1186/s13058-024-01841-6

We compared the survival rates of women with breast cancer (BC) detected within versus outside the mammography screening program (MSP) "donna". We merged data from the MSP with the data from corresponding cancer registries to categorize BC cases as within MSP (screen-detected and interval carcinomas) and outside the MSP. We analyzed the tumor stage distribution, tumor characteristics and the survival of the women. We further estimated hazard ratios using Cox-regressions to account for different characteristics between groups and corrected the survival rates for lead-time bias. We identified 1057 invasive (ICD-10: C50) and in-situ (D05) BC cases within the MSP and 1501 outside the MSP between 2010 and 2019 in the Swiss cantons of St. Gallen and Grisons. BC within the MSP had a higher share of stage I carcinoma (46.5% vs. 33.0%; p