Integrated Serologic Surveillance of Population Immunity and Disease Transmission

Antibodies are unique among biomarkers in their ability to identify persons with protective immunity to vaccine-preventable diseases and to measure past exposure to diverse pathogens. Most infectious disease surveillance maintains a single-disease focus, but broader testing of existing serologic sur...

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Bibliographic Details
Published in:Emerging infectious diseases 2018-07, Vol.24 (7), p.1188-1194
Main Authors: Arnold, Benjamin F, Scobie, Heather M, Priest, Jeffrey W, Lammie, Patrick J
Format: Article
Language:English
Subjects:
Analysis
Antibodies
Communicable Disease Control - methods
communicable diseases
Communicable Diseases - epidemiology
Communicable Diseases - immunology
Communicable Diseases - transmission
Disease transmission
emerging
Host-Pathogen Interactions - immunology
Humans
Immunologic Surveillance
Innovations
Integrated Serologic Surveillance of Population Immunity and Disease Transmission
malaria
Population Surveillance - methods
Seroepidemiologic Studies
Serologic Tests
Surveys
Tetanus antitoxin
vaccination
Vaccines
Viral antibodies
Waterborne infections
World health
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Summary:Antibodies are unique among biomarkers in their ability to identify persons with protective immunity to vaccine-preventable diseases and to measure past exposure to diverse pathogens. Most infectious disease surveillance maintains a single-disease focus, but broader testing of existing serologic surveys with multiplex antibody assays would create new opportunities for integrated surveillance. In this perspective, we highlight multiple areas for potential synergy where integrated surveillance could add more value to public health efforts than the current trend of independent disease monitoring through vertical programs. We describe innovations in laboratory and data science that should accelerate integration and identify remaining challenges with respect to specimen collection, testing, and analysis. Throughout, we illustrate how information generated through integrated surveillance platforms can create new opportunities to more quickly and precisely identify global health program gaps that range from undervaccination to emerging pathogens to multilayered health disparities that span diverse communicable diseases.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2407.171928