Effects of air pollution exposure on social behavior: a synthesis and call for research

Background There is a growing literature from both epidemiologic and experimental animal studies suggesting that exposure to air pollution can lead to neurodevelopmental and neuropsychiatric disorders. Here, we suggest that effects of air pollutant exposure on the brain may be even broader, with the...

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Bibliographic Details
Published in:Environmental health 2021-06, Vol.20 (1), p.1-72, Article 72
Main Authors: Weitekamp, Chelsea A, Hofmann, Hans A
Format: Article
Language:English
Subjects:
Air cleanliness
Air pollution
Air pollution effects
Autism
Brain
Brain research
Carbon monoxide
Decision making
Dopamine
Environmental aspects
Environmental health
Epidemiology
Exposure
Gene expression
Health aspects
Interpersonal relations
Laboratory tests
Mental disorders
Nervous system
Neurodevelopmental disorders
Neurotoxicity
Nitrogen dioxide
Outdoor air quality
Oxidative stress
Ozone
Particulate matter
Pollutants
Psychological aspects
Public health
Review
Sexual behavior
Social aspects
Social behavior
Social decision-making network
Substrates
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Summary:Background There is a growing literature from both epidemiologic and experimental animal studies suggesting that exposure to air pollution can lead to neurodevelopmental and neuropsychiatric disorders. Here, we suggest that effects of air pollutant exposure on the brain may be even broader, with the potential to affect social decision-making in general. Methods We discuss how the neurobiological substrates of social behavior are vulnerable to air pollution, then briefly present studies that examine the effects of air pollutant exposure on social behavior-related outcomes. Results Few experimental studies have investigated the effects of air pollution on social behavior and those that have focus on standard laboratory tests in rodent model systems. Nonetheless, there is sufficient evidence to support a critical need for more research. Conclusion For future research, we suggest a comparative approach that utilizes diverse model systems to probe the effects of air pollution on a wider range of social behaviors, brain regions, and neurochemical pathways. Keywords: Air pollution, Social behavior, Particulate matter, Ozone, Social decision-making network, Dopamine, Sex steroids, Inhalation, Hazardous air pollutants
ISSN:1476-069X
1476-069X
DOI:10.1186/s12940-021-00761-8