A differential equation, deduced from a DNA-type genetic algorithm with the lagging-strand-biased mutagenesis

Recent evidence indicated that the significant fidelity difference existed between the leading and lagging-strand. Using a 2-D DNA-type genetic algorithm (GA), we have shown that the lagging-stand-biased mutagenesis (disparity mutagenesis) has a significant advantage in the promotion of evolution, c...

Full description

Saved in:
Bibliographic Details
Published in:Heliyon 2022-03, Vol.8 (3), p.e09155-e09155, Article e09155
Main Authors: Fujihara, Ichiro, Furusawa, Mitsuru
Format: Article
Language:English
Subjects:
2D DNA-type GA
Differential equation
Disparity mutagenesis
Evolution
Genetic algorithm
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Recent evidence indicated that the significant fidelity difference existed between the leading and lagging-strand. Using a 2-D DNA-type genetic algorithm (GA), we have shown that the lagging-stand-biased mutagenesis (disparity mutagenesis) has a significant advantage in the promotion of evolution, compared with the traditional parity mutagenesis model. Our aim of the present study was to deduce a differential equation which well reflected the result of simulations. The analytical solution of the differential equation obtained was in good agreement with the results of the simulation experiment. Comparing the results of the disparity mutagenesis with those of the parity one, the characteristics of the disparity mutagenesis were discussed in terms of relative mutation rates between the lagging and leading strands. Conditions of the extinction of a species were also discussed. Differential equation; Genetic algorithm; 2D DNA-type GA; Disparity mutagenesis; Evolution
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2022.e09155