The Neutrophil-to-Albumin Ratio as a New Predictor of All-Cause Mortality in Patients with Heart Failure

Neutrophils and albumin had been shown to be independent predictors of mortality from various diseases. Purpose of this study was to investigate the effect of neutrophil-to-albumin ratio (NPAR) as an independent predictor of mortality in heart failure (HF) patients. Data were extracted from Medical...

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Bibliographic Details
Published in:Journal of inflammation research 2022-01, Vol.15, p.701-713
Main Authors: Hu, Zesong, Wang, Jie, Xue, Yangjing, Zhang, Qianqian, Xu, Qianqian, Ji, Kangting, Yin, Ripeng
Format: Article
Language:English
Subjects:
Albumin
all-cause mortality
Analysis
Blood pressure
Cardiac arrhythmia
Cardiac patients
Congestive heart failure
Correlation analysis
Creatinine
Disease
Ethnicity
Gender
Heart failure
Heart rate
Hospital patients
Hospitals
Hypertension
Inflammation
Intensive care
Laboratories
Leukocytes (neutrophilic)
Massachusetts
Medical advice systems
Medical colleges
Medical research
Medicine, Experimental
Mortality
neutrophil-to-albumin ratio
Neutrophils
Nitrogen
Older people
Original Research
Patient outcomes
Patients
Physiology
Structured Query Language-SQL
Taiwan
Vital signs
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Summary:Neutrophils and albumin had been shown to be independent predictors of mortality from various diseases. Purpose of this study was to investigate the effect of neutrophil-to-albumin ratio (NPAR) as an independent predictor of mortality in heart failure (HF) patients. Data were extracted from Medical Information Mart for Intensive Care-III database. Primary outcome was 30-day mortality, secondary outcomes were in-hospital, 90-day, 365-day mortality, length of stay (LOS) in hospital. Cox proportional hazards regression model and receiver operating characteristic (ROC) curve analysis and Pearson correlation analysis were used. The HR (95% CI) values of the mid-tertile and the upper tertile were 1.27 (1.01 to 1.59) and 2.29 (1.87 to 2.81) in 30-day mortality compared with the reference. The trend continued after adjusted for demographic and clinical variables. In the secondary outcomes were the same trends. The data of the Second Affiliated Hospital of Wenzhou Medical University showed the correlation coefficient between hospital LOS with NPAR. NPAR was an independent factor of mortality in HF patients, which was correlated with hospital LOS. Our results need to be verified by prospective studies.
ISSN:1178-7031
1178-7031
DOI:10.2147/JIR.S349996