Thyroid function and anti-thyroid antibodies in Iranian patients with type 1 diabetes mellitus: influences of age and sex

Type 1 diabetes mellitus is frequently associated with autoimmune thyroid disease (ATD).Genetic susceptibility for autoantibody formation in association with ATD and type 1 diabetes mellitus has been described with varying frequencies, but there is still debate about its prevailing situation in Iran...

Full description

Saved in:
Bibliographic Details
Published in:Iranian journal of allergy, asthma, and immunology asthma, and immunology, 2008-03, Vol.7 (1), p.31-36
Main Authors: Sharifi, Faranak, Ghasemi, Leila, Mousavinasab, Nouraddin
Format: Article
Language:English
Subjects:
Adult
Age Factors
Anti-TG
Anti-TPO
Autoantibodies - blood
Autoantibodies - immunology
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - immunology
Diabetes Mellitus, Type 1 - physiopathology
Female
Genetic Predisposition to Disease
Humans
Iodide Peroxidase - immunology
Iran
Iranian patients
Male
Prevalence
Sex Factors
Thyroglobulin - immunology
Thyroid Function Tests
Thyroid Gland - immunology
Thyroid Gland - physiopathology
Thyroiditis, Autoimmune - blood
Thyroiditis, Autoimmune - complications
Thyroiditis, Autoimmune - immunology
Thyroiditis, Autoimmune - physiopathology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Type 1 diabetes mellitus is frequently associated with autoimmune thyroid disease (ATD).Genetic susceptibility for autoantibody formation in association with ATD and type 1 diabetes mellitus has been described with varying frequencies, but there is still debate about its prevailing situation in Iran. We have therefore investigated the prevalence of anti-thyroid peroxidase (anti-TPO) and anti thyroglubolin (Anti TG) antibodies in type 1 diabetic patients, and compared the effect of age and sex on the thyroid autoimmunity in patients with type 1 diabetes mellitus in Iran.Ninety one subjects with type 1 diabetes mellitus and one hundred and sixty three unrelated normal controls under the age of thirty years were recruited for the detection of anti-TPO and anti-TG. Radio Immuno Assay and chemiluminescence methods were used for anti-TPO and anti-TG detection respectively.Among 91 type 1 diabetic patients, 36 (39.6%) were positive for anti-TPO and 27(30%) were positive for antiTG. Anti-TPO antibodies were detected only in 6.7% of control group. Comparing with those without thyroid autoimmunity, there was a female preponderance for the type 1 diabetic patients with thyroid autoimmunity (female: male, 28:14 vs. 28:20 respectively). Among the type 1 diabetic patients those with thyroid autoimmunity, tended to be older (p: 0.04) and to have higher TSH concentration (p: 0.03). Patients with high anti-TPO levels had longer duration of diabetes (P: 0.02).The presence of anti-TPO in 39.6% of our type 1 diabetic patients comparing with 8.5% of normal subjects confirmed the strong association of ATD and type 1 diabetes mellitus.
ISSN:1735-1502
1735-5249