Serum zinc deficiency could be associated with dementia conversion in Parkinson's disease

Association between heavy metals and Parkinson's disease (PD) is well noted, but studies regarding heavy metal levels and non-motor symptoms of PD, such as PD's dementia (PD-D), are lacking. In this retrospective cohort study, we compared five serum heavy metal levels (Zn, Cu, Pb, Hg, and...

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Published in:Frontiers in aging neuroscience 2023-04, Vol.15, p.1132907-1132907
Main Authors: Lee, Jieun, Park, Suyeon, Jang, Wooyoung
Format: Article
Language:English
Subjects:
Aging Neuroscience
Alzheimer's disease
Cholinesterase inhibitors
Cognitive ability
Copper
Correlation analysis
Dementia
Dementia disorders
heavy metal
Heavy metals
Laboratories
Manganese
Mass spectrometry
Medical records
Movement disorders
Neurodegeneration
Neurodegenerative diseases
Nutrient deficiency
Parkinson's disease
Risk factors
Scientific imaging
Zinc
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Summary:Association between heavy metals and Parkinson's disease (PD) is well noted, but studies regarding heavy metal levels and non-motor symptoms of PD, such as PD's dementia (PD-D), are lacking. In this retrospective cohort study, we compared five serum heavy metal levels (Zn, Cu, Pb, Hg, and Mn) of newly diagnosed PD patients (  = 124). Among 124 patients, 40 patients were later converted to Parkinson's disease dementia (PD-D), and 84 patients remained without dementia during the follow-up time. We collected clinical parameters of PD and conducted correlation analysis with heavy metal levels. PD-D conversion time was defined as the initiation time of cholinesterase inhibitors. Cox proportional hazard models were used to identify factors associated with dementia conversion in PD subjects. Zn deficiency was significant in the PD-D group than in the PD without dementia group (87.53 ± 13.20 vs. 74.91 ± 14.43,  
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2023.1132907