Clinical, Histopathological Characteristics and Immunohistochemical Findings in Lichen Planus Pigmentosus

Lichen planus pigmentosus (LPP), a rare variant of lichen planus, is reported in various ethnic groups, more often from the Indian subcontinent and the Middle East. Although the condition is encountered quite often by dermatologists of this region, the data on the clinical, pathological, and immunoh...

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Bibliographic Details
Published in:Indian journal of dermatology 2017-11, Vol.62 (6), p.612-617
Main Authors: Bhat, Ramesh M, Mathanda, Teena Ramesh, Jayaprakash, C S, Dandakeri, Sukumar
Format: Article
Language:English
Subjects:
Apoptosis
Care and treatment
CD4
CD45RO (UCHL-1)
CD68
CD8
Cell proliferation
Cytotoxicity
Dermatology
Development and progression
Diagnosis
immunohistochemistry
Inflammation
Keratinocytes
Lichen planus
lichen planus pigmentosus
Lymphocytes
Macrophages
Middle age
Minority & ethnic groups
Original
Pigments
Skin
Skin diseases
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Summary:Lichen planus pigmentosus (LPP), a rare variant of lichen planus, is reported in various ethnic groups, more often from the Indian subcontinent and the Middle East. Although the condition is encountered quite often by dermatologists of this region, the data on the clinical, pathological, and immunohistochemical (IHC) aspects of LPP are limited. This prospective study is aimed towards filling this lacuna. Data were collected from thirty clinically diagnosed cases of LPP who presented to the dermatology outpatient department. Skin biopsy and blood investigations were conducted and the specimens were further analyzed for their histopathological features and IHC staining for CD4 , CD8 T-lymphocyte subsets along with CD45RO (UCHL-1), and CD68. The results were statistically analyzed. The study showed a female preponderance (56.7%). Photo aggravation as a precipitating cause was seen in 40% of the individuals. The lesions with duration
ISSN:0019-5154
1998-3611
DOI:10.4103/ijd.IJD_148_17