Virological and Serological Discordant Profiles in COVID-19 Pneumonia: Two Atypical Clinical Cases

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is primarily diagnosed through viral RNA positivity in nasopharyngeal swabs, and it is associated with the early detection of specific immunoglobulins to SARS-CoV-2 proteins. We describe two moderate coronavirus disease 2019 (COV...

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Bibliographic Details
Published in:Frontiers in immunology 2020-10, Vol.11, p.580867-580867
Main Authors: Ranzenigo, Martina, Pastori, Claudia, Siracusano, Gabriel, Pariani, Elena, Uberti-Foppa, Caterina, Lopalco, Lucia
Format: Article
Language:English
Subjects:
Aged
antibodies
Antibodies, Neutralizing - blood
Antibodies, Neutralizing - immunology
Antibodies, Viral - blood
Clinical Laboratory Techniques
Coronavirus Infections - diagnosis
Coronavirus Infections - immunology
Coronavirus Infections - virology
COVID-19
COVID-19 Testing
Female
Humans
Immunology
Male
Nasal Mucosa - virology
neutralizing antibodies
Pandemics
PCR
Pneumonia, Viral - diagnosis
Pneumonia, Viral - immunology
Pneumonia, Viral - virology
Real-Time Polymerase Chain Reaction
RNA, Viral - analysis
SARS-CoV-2
Serologic Tests
viral RNA
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Summary:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is primarily diagnosed through viral RNA positivity in nasopharyngeal swabs, and it is associated with the early detection of specific immunoglobulins to SARS-CoV-2 proteins. We describe two moderate coronavirus disease 2019 (COVID-19) patients with WHO score 4/5 at the time of hospitalization, pneumonia, and oxygen saturation
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.580867