Placenta-derived exosomes: potential biomarkers of preeclampsia

Preeclampsia remains a leading cause of maternal and fetal mortality, due to ineffective treatment and diagnostic strategies, compounded by the lack of clarity on the etiology of the disorder. Although several clinical and biological markers of preeclampsia have been evaluated, they have proven to b...

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Bibliographic Details
Published in:International Journal of Nanomedicine 2017-01, Vol.12, p.8009-8023
Main Authors: Pillay, Preenan, Moodley, Kogi, Moodley, Jagidesa, Mackraj, Irene
Format: Article
Language:English
Subjects:
Biological markers
Biomarkers
Biomarkers - analysis
Blood pressure
Cancer
Cardiovascular disease
Care and treatment
Clinical medicine
Complications and side effects
Cytokines
Diagnosis
Etiology
Exosomes - pathology
Female
Fetuses
Health aspects
Humans
Hypertension
Laboratories
Medicine
Mortality
Pathogenesis
Placenta
Placenta - cytology
Placenta - pathology
Placental-derived exosomes
Pre-Eclampsia - diagnosis
Pre-Eclampsia - pathology
Preeclampsia
Pregnancy
Prognosis
Review
Risk factors
Stem cells
Veins & arteries
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Summary:Preeclampsia remains a leading cause of maternal and fetal mortality, due to ineffective treatment and diagnostic strategies, compounded by the lack of clarity on the etiology of the disorder. Although several clinical and biological markers of preeclampsia have been evaluated, they have proven to be ineffective in providing a definitive diagnosis during the various stages of the disorder. Exosomes have emerged as ideal biomarkers of pathological states, such as cancer, and have more recently gained interest in pregnancy-related complications, due to their role in cellular communication in normal and complicated pregnancies. This occurs as a result of the specific placenta-derived exosomal molecular cargo, which may be involved in normal pregnancy-associated immunological events, such as the maintenance of maternal-fetal tolerance. This review provides perspectives on placenta-derived exosomes as possible biomarkers for the diagnosis/prognosis of preeclampsia. Using keywords, online databases were searched to identify relevant publications to review the potential use of placenta-derived exosomes as biomarkers of preeclampsia.
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S142732