Serum concentration of extracellular cold-inducible RNA-binding protein is associated with respiratory failure in COVID-19

Uncontrolled release of damage-associated molecular patterns (DAMPs) is suggested to be a major trigger for the dysregulated host immune response that leads to severe COVID-19. Cold-inducible RNA-binding protein (CIRP), is a newly identified DAMP that aggravates inflammation and tissue injury, and i...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology 2022-07, Vol.13, p.945603
Main Authors: Schagatay, Felix, Diamant, Klara, Lidén, Mats, Edin, Alicia, Athlin, Simon, Hultgren, Olof, Ahlm, Clas, Forsell, Mattias N E, Savilampi, Johanna, Normark, Johan, Lange, Anna, Cajander, Sara
Format: Article
Language:English
Subjects:
Alarmins
Anaesthesiology
anestesiologi
CIRP
COVID-19
DAMPs
eCIRP
Humans
Hypoxia - complications
Immunology
inflammation
Oxygen
Respiratory Distress Syndrome
Respiratory Insufficiency - etiology
RNA-Binding Proteins
severity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Uncontrolled release of damage-associated molecular patterns (DAMPs) is suggested to be a major trigger for the dysregulated host immune response that leads to severe COVID-19. Cold-inducible RNA-binding protein (CIRP), is a newly identified DAMP that aggravates inflammation and tissue injury, and induces respiratory failure in sepsis. Whether CIRP contributes to the pathogenesis of respiratory failure in COVID-19 has not yet been explored. To investigate if the concentration of extracellular CIRP (eCIRP) in serum associates with respiratory failure and lung involvement by chest computed tomography (CT) in COVID-19. Herein we report a prospective observational study of patients with COVID-19 included at two University Hospitals in Sweden between April 2020 and May 2021. Serum from hospitalized patients in Örebro (N=97) were used to assess the association between eCIRP and the level of respiratory support and its correlation with pulmonary involvement on chest CT and inflammatory biomarkers. A cohort of hospitalized and non-hospitalized patients from Umeå (N=78) was used as an external validation cohort. The severity of disease was defined according to the highest degree of respiratory support; mild disease (no oxygen), non-severe hypoxemia (conventional oxygen or high-flow nasal oxygen, HFNO
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.945603