The Protective Effect of Magnolol in Osteoarthritis: In vitro and in vivo Studies

• Published in: Frontiers in pharmacology 2019-04, Vol.10, p.393-393
• Main Authors: Hu, Zhi-Chao, Luo, Zu-Cheng, Jiang, Bing-Jie, Fu, Xin, Xuan, Jiang-Wei, Li, Xiao-Bin, Bian, Yu-Jie, Ni, Wen-Fei, Xue, Ji-Xin
• Format: Article
• Language: English
• Subjects: inflammation; interleukin-1 beta; magnolol; osteoarthritis; Pharmacology; PI3K/Akt/NF-κB
• ISSN: 1663-9812; 1663-9812
• DOI: 10.3389/fphar.2019.00393

Osteoarthritis (OA), defined as a long-term progressive joint disease, is characterized by cartilage impairment and erosion. In recent decades, magnolol, as a type of lignin extracted from , has been proved to play a potent anti-inflammatory role in various diseases. The current research sought to examine the latent mechanism of magnolol and its protective role in alleviating the progress of OA as well as experimentations. , the over-production of Nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6), induced by interleukin-1 beta (IL-1β), were all inhibited notably by magnolol in a concentration-dependent manner. Moreover, magnolol could also downregulate the expression of metalloproteinase 13 (MMP13) and thrombospondin motifs 5 (ADAMTS5). All these changes ultimately led to the deterioration of the extracellular matrix (ECM) induced by IL-1β. Mechanistically, magnolol suppressed the activation of PI3K/Akt/NF-κB pathway. Furthermore, a powerful binding capacity between magnolol and PI3K was also revealed in our molecular docking research. In addition, magnolol-induced protective effects in OA development were also detected in a mouse model. In summary, this research suggested that magnolol possessed a new therapeutic potential for the development of OA.