Host Cell Entry and Neutralization Sensitivity of SARS-CoV-2 Lineages B.1.620 and R.1

The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) facilitates viral entry into host cells and is the key target for neutralizing antibodies. The SARS-CoV-2 lineage B.1.620 carries fifteen mutations in the S protein and is spread in Africa, the US and Europe, while...

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Bibliographic Details
Published in:Viruses 2022-11, Vol.14 (11), p.2475
Main Authors: Sidarovich, Anzhalika, Krüger, Nadine, Rocha, Cheila, Graichen, Luise, Kempf, Amy, Nehlmeier, Inga, Lier, Martin, Cossmann, Anne, Stankov, Metodi V, Schulz, Sebastian R, Behrens, Georg M N, Jäck, Hans-Martin, Pöhlmann, Stefan, Hoffmann, Markus
Format: Article
Language:English
Subjects:
ACE2
Angiotensin-Converting Enzyme 2
Antibodies
Antibodies, Neutralizing
Antibodies, Viral
B.1.620
Brief Report
cell entry
Cell lines
Coronaviruses
COVID-19
COVID-19 vaccines
Data analysis
Health aspects
Host-virus relationships
Humans
Laboratories
Mutation
neutralization
Peptidyl-Dipeptidase A - metabolism
Plasmids
Proteins
R.1
SARS-CoV-2
SARS-CoV-2 - genetics
Severe acute respiratory syndrome coronavirus 2
Software
Spike Glycoprotein, Coronavirus
spike protein
Vaccines
Viral proteins
Virus Internalization
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Summary:The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) facilitates viral entry into host cells and is the key target for neutralizing antibodies. The SARS-CoV-2 lineage B.1.620 carries fifteen mutations in the S protein and is spread in Africa, the US and Europe, while lineage R.1 harbors four mutations in S and infections were observed in several countries, particularly Japan and the US. However, the impact of the mutations in B.1.620 and R.1 S proteins on antibody-mediated neutralization and host cell entry are largely unknown. Here, we report that these mutations are compatible with robust ACE2 binding and entry into cell lines, and they markedly reduce neutralization by vaccine-induced antibodies. Our results reveal evasion of neutralizing antibodies by B.1.620 and R.1, which might have contributed to the spread of these lineages.
ISSN:1999-4915
1999-4915
DOI:10.3390/v14112475