Nanosystems in Cardiovascular Medicine: Advancements, Applications, and Future Perspectives

Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality globally. Despite significant advancements in the development of pharmacological therapies, the challenges of targeted drug delivery to the cardiovascular system persist. Innovative drug-delivery systems have been devel...

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Bibliographic Details
Published in:Pharmaceutics 2023-07, Vol.15 (7), p.1935
Main Authors: Omidian, Hossein, Babanejad, Niloofar, Cubeddu, Luigi X
Format: Article
Language:English
Subjects:
Atherosclerosis
Blood clots
Cardiovascular agents
Cardiovascular disease
Cardiovascular diseases
cardiovascular diseases (CVDs)
Cholesterol
Clinical outcomes
Cytokines
Drug delivery systems
Drug therapy
Drugs
Endothelium
Health aspects
Heart attacks
Hypertension
Inflammation
innovative diagnosis and therapies
Investigations
Ischemia
Magnetic resonance imaging
Medical research
Medicine, Experimental
Nanoparticles
Nanotechnology
Oxidative stress
Peptides
Review
targeted drug delivery
Vehicles
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Summary:Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality globally. Despite significant advancements in the development of pharmacological therapies, the challenges of targeted drug delivery to the cardiovascular system persist. Innovative drug-delivery systems have been developed to address these challenges and improve therapeutic outcomes in CVDs. This comprehensive review examines various drug delivery strategies and their efficacy in addressing CVDs. Polymeric nanoparticles, liposomes, microparticles, and dendrimers are among the drug-delivery systems investigated in preclinical and clinical studies. Specific strategies for targeted drug delivery, such as magnetic nanoparticles and porous stent surfaces, are also discussed. This review highlights the potential of innovative drug-delivery systems as effective strategies for the treatment of CVDs.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics15071935