Activating effective functional hand movements in individuals with complete tetraplegia through neural stimulation

Individuals with complete cervical spinal cord injury suffer from a permanent paralysis of upper limbs which prevents them from achieving most of the activities of daily living. We developed a neuroprosthetic solution to restore hand motor function. Electrical stimulation of the radial and median ne...

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Bibliographic Details
Published in:Scientific reports 2022-10, Vol.12 (1), p.16189-16189, Article 16189
Main Authors: Coste, Christine Azevedo, William, Lucie, Fonseca, Lucas, Hiairrassary, Arthur, Andreu, David, Geffrier, Antoine, Teissier, Jacques, Fattal, Charles, Guiraud, David
Format: Article
Language:English
Subjects:
639/166/985
692/308/575
Activities of daily living
Electrical stimuli
Electrodes
General anesthesia
Humanities and Social Sciences
Life Sciences
multidisciplinary
Nerves
Paralysis
Patients
Prosthetics
Quality of life
Recovery of function
Science
Science (multidisciplinary)
Spinal cord
Spinal cord injuries
Surgery
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Summary:Individuals with complete cervical spinal cord injury suffer from a permanent paralysis of upper limbs which prevents them from achieving most of the activities of daily living. We developed a neuroprosthetic solution to restore hand motor function. Electrical stimulation of the radial and median nerves by means of two epineural electrodes enabled functional movements of paralyzed hands. We demonstrated in two participants with complete tetraplegia that selective stimulation of nerve fascicles by means of optimized spreading of the current over the active contacts of the multicontact epineural electrodes induced functional and powerful grasping movements which remained stable over the 28 days of implantation. We also showed that participants were able to trigger the activation of movements of their paralyzed limb using an intuitive interface controlled by voluntary actions and that they were able to perform useful functional movements such as holding a can and drinking through a straw.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-19906-x