Anti-Hu Antibody-Associated Adie's Pupil and Paraneoplastic Sensorimotor Polyneuropathy Caused by Primary Mediastinal Small Cell Carcinoma

We report a woman with unilateral Adie's pupil associated with peripheral sensorimotor polyneuropathy, elevated anti-Hu antibody, and primary mediastinal small cell carcinoma (SCC). To our knowledge, this is the first report of Adie's pupil in a patient with mediastinal SCC. Although rare,...

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Bibliographic Details
Published in:Frontiers in neurology 2019-11, Vol.10, p.1236
Main Authors: Zhang, Lei, Luo, Si, Jin, Hui, Lv, Xueman, Chen, Jiajun
Format: Article
Language:English
Subjects:
Adie's pupil
anti-Hu antibody
Neurology
paraneoplastic neurological syndrome
peripheral neuropathy
small cell carcinoma
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Summary:We report a woman with unilateral Adie's pupil associated with peripheral sensorimotor polyneuropathy, elevated anti-Hu antibody, and primary mediastinal small cell carcinoma (SCC). To our knowledge, this is the first report of Adie's pupil in a patient with mediastinal SCC. Although rare, Adie's pupil and sensorimotor polyneuropathy may be the first manifestation of cancer. Its rapid recognition facilitates an early diagnosis and treatment.
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2019.01236